SKN7 kinase-regulated stress-responsive transcription factor SKN7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SKN7
Gene description: kinase-regulated stress-responsive transcription factor SKN7
Primary source: FungiDB:YHR206W
Locus tag: YHR206W
See related: SGD:S000001249; AllianceGenome:SGD:S000001249; VEuPathDB:YHR206W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BRY1; POS9
Summary: Enables DNA-binding transcription factor activity and phosphorelay response regulator activity. Involved in several processes, including regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to singlet oxygen; and transcription elongation from RNA polymerase II promoter. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SKN7 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (512732..514600)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The deletion of transcription factors Yap1p or Skn7p was sufficient to disrupt the establishment of the second degradation phase of hydrogen peroxide, but not the initial phase.
Title: High-resolution kinetics and modeling of hydrogen peroxide degradation in live cells.
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Title: Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA
Title: Complex regulation of Hsf1-Skn7 activities by the catalytic subunits of PKA in Saccharomyces cerevisiae: experimental and computational evidences.
Deleting the TRX2 gene causes Skn7p hyperphosphorylation under oxidative stress conditions.
Title: Trx2p-dependent regulation of Saccharomyces cerevisiae oxidative stress response by the Skn7p transcription factor under respiring conditions.
We present here evidence for a DNA-independent interaction between the Skn7 and Yap1 proteins that involves the receiver domain of Skn7p and the cysteine-rich domains of Yap1. [Skn7]
Title: Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response.
Association of Yap1 with Skn7 in the nucleus is a prerequisite for Skn7 phosphorylation and the activation of oxidative stress response genes.
Title: Oxidative stress function of the Saccharomyces cerevisiae Skn7 receiver domain.
the Ccr4-Not complex has a critical role in the mechanism of activation of Skn7 that is dependent upon the Srb10 kinase
Title: The Ccr4-not complex regulates Skn7 through Srb10 kinase.
Transcription factor Skn7p was important for both acute and chronic responses to H2O2
Title: Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor.
Novel Yap1p and Skn7p binding sites responsible for activation of oxidative stress genes were identified in the CCP1 promoter.
Title: Identification of novel Yap1p and Skn7p binding sites involved in the oxidative stress response of Saccharomyces cerevisiae.
The expression pattern of four oxidative stress genes in a yap1, skn7 and wild-type strain and the sensitivity of the corresponding mutants exposed to oxidative stress conditions proved a role of Yap1p and Skn7p in the defence against singlet oxygen.
Title: The role of Yap1p and Skn7p-mediated oxidative stress response in the defence of Saccharomyces cerevisiae against singlet oxygen.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorelay response regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay response regulator activity	IEA Inferred from Electronic Annotation more info
enables phosphorelay response regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to singlet oxygen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinase-regulated stress-responsive transcription factor SKN7

NP_012076.3

Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

512732..514600

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179337.3 → NP_012076.3 TPA: kinase-regulated stress-responsive transcription factor SKN7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012076.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLF5, E9P959, P38889, P39747

UniProtKB/TrEMBL

A0A6A5PYR6, A6ZTB3, B3LSW7, C7GN91, C8ZA07, N1P9I9

Conserved Domains (2) summary

COG5169
Location:75 → 350

HSF1; Heat shock transcription factor [Transcription]

cd17546
Location:379 → 488

REC_hyHK_CKI1_RcsC-like; phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC