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FLO5 flocculin FLO5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856618, updated on 19-Jun-2024

Summary

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Gene symbol
FLO5
Gene description
flocculin FLO5
Primary source
FungiDB:YHR211W
Locus tag
YHR211W
See related
SGD:S000001254; AllianceGenome:SGD:S000001254; VEuPathDB:YHR211W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mannose binding activity. Involved in cell-substrate adhesion and flocculation. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FLO5 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (525392..528619)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Different genetic responses to oenological conditions between a flocculent wine yeast and its FLO5 deleted strain: Insights from the transcriptome. Di Gianvito P, et al. Food Res Int, 2018 Dec. PMID 30361014
  2. Cloning and analysis of a FLO5 flocculation gene from S. cerevisiae. Bidard F, et al. Curr Genet, 1994 Mar. PMID 7923404
  3. Localization of the dominant flocculation genes FLO5 and FLO8 of Saccharomyces cerevisiae. Teunissen AW, et al. Yeast, 1995 Jun 30. PMID 7668043
  4. Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae. Stratford M. Yeast, 1989 Apr. PMID 2665372
  5. A mannose-binding protein from the cell surface of flocculent Saccharomyces cerevisiae (NCIM 3528): its role in flocculation. Javadekar VS, et al. Yeast, 2000 Jan 30. PMID 10641033

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studied transcriptome of a flocculent Saccharomyces cerevisiae strain with regards to the role of FLO5 during wine fermentation.
    Title: Different genetic responses to oenological conditions between a flocculent wine yeast and its FLO5 deleted strain: Insights from the transcriptome.
  2. importance of FLO5 gene in development of high flocculent characteristic of wine yeasts
    Title: Genetic diversity of FLO1 and FLO5 genes in wine flocculent Saccharomyces cerevisiae strains.
  3. Data show that the Flo5A structure suggests a model for recognition, where social non-self- instead of unsocial self-interactions are favored.
    Title: Structural basis of flocculin-mediated social behavior in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-mannose binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flocculation IEA
Inferred from Electronic Annotation
more info
  
involved_in flocculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flocculin FLO5
NP_012081.1
  • Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    525392..528619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179342.1 → NP_012081.1  TPA: flocculin FLO5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLG0, P38894
    UniProtKB/TrEMBL
    A0A8H4C2D0, K9LCY6
    Conserved Domains (3) summary
    pfam00624
    Location:503 → 540
    Flocculin; Flocculin repeat
    pfam07691
    Location:100 → 249
    PA14; PA14 domain
    pfam13928
    Location:784 → 825
    Flocculin_t3; Flocculin type 3 repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38894.1

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