UTR2 chitin transglycosylase UTR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UTR2
Official Full Name: chitin transglycosylase UTR2
Primary source: SGD:S000000766
Locus tag: YEL040W
See related: AllianceGenome:SGD:S000000766; FungiDB:YEL040W; VEuPathDB:YEL040W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRH2
Summary: Enables glycosyltransferase activity. Involved in cell wall chitin metabolic process and fungal-type cell wall organization. Located in cellular bud neck septin ring and fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UTR2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (78053..79456)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ssays of heterologously expressed transglycosylases ScGas1, ScCrh1, and ScCrh2 from the yeast Saccharomyces cerevisiae, CaPhr1 and CaPhr2 from Candida albicans, and of a plant xyloglucan endotransglycosylase (XET) are demonstrated.
Title: Two Variants of a High-Throughput Fluorescent Microplate Assay of Polysaccharide Endotransglycosylases.
catalytic properties of Crh2 yeast cell wall transglycosylases
Title: A novel fluorescence assay and catalytic properties of Crh1 and Crh2 yeast cell wall transglycosylases.
model in which the unfolded protein response (UPR)/yapsin-mediated extracellular release of overexpressed Utr2/Crh2-HA or -GFP is an alternative pathway for the removal of excess or misfolded secretory proteins
Title: Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae.
Crh1 and Crh2 catalyze the transfer of chitin to both beta(1-3)- and beta(1-6)glucan in cell wall.
Title: Two novel techniques for determination of polysaccharide cross-links show that Crh1p and Crh2p attach chitin to both beta(1-6)- and beta(1-3)glucan in the Saccharomyces cerevisiae cell wall.
Crh1p and Crh2p act as transglycosylases in vivo and in vitro
Title: Assembly of the yeast cell wall. Crh1p and Crh2p act as transglycosylases in vivo and in vitro.
Study indicates that Crh1p and Crh2p, homologues of glycosyltransferases, ferry chitin chains from chitin synthase III to beta(1-6)glucan.
Title: Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glycosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in chitin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chitin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitin transglycosylase UTR2

NP_010874.3

Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

78053..79456

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178855.3 → NP_010874.3 TPA: chitin transglycosylase UTR2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010874.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLK9, P32623, Q6B1R6

UniProtKB/TrEMBL

G2WCJ3

Conserved Domains (2) summary

cd02183
Location:91 → 302

GH16_fungal_CRH1_transglycosylase; glycosylphosphatidylinositol-glucanosyltransferase

cd06923
Location:25 → 71

ChtBD1_GH16; Hevein or Type 1 chitin binding domain subfamily that co-occurs with family 16 glycosyl hydrolases