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ANP1 Anp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856675, updated on 29-Jun-2024

Summary

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Gene symbol
ANP1
Gene description
Anp1p
Primary source
FungiDB:YEL036C
Locus tag
YEL036C
See related
SGD:S000000762; AllianceGenome:SGD:S000000762; VEuPathDB:YEL036C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GEM3; MNN8
Summary
Contributes to alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in Golgi cis cisterna. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ANP1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (83050..84552, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative acireductone synthase UTR4 Neighboring gene Rad23p Neighboring gene Utr5p Neighboring gene translation elongation factor eIF-5A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An extensive deletion causing overproduction of yeast iso-2-cytochrome c. McKnight GL, et al. Cell, 1981 Aug. PMID 6269746
  2. Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage. Acevedo-Torres K, et al. Environ Mol Mutagen, 2009 May. PMID 19197988, Free PMC Article
  3. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. Chapman RE, et al. EMBO J, 1994 Oct 17. PMID 7957057, Free PMC Article
  4. Yeast invertase polymorphism is correlated with variable states of oligosaccharide chain phosphorylation. Frevert J, et al. Proc Natl Acad Sci U S A, 1982 Oct. PMID 6755465, Free PMC Article
  5. Protein glycosylation defects in the Saccharomyces cerevisiae mnn7 mutant class. Support for the stop signal proposed for regulation of outer chain elongation. Ballou L, et al. J Biol Chem, 1989 Jul 15. PMID 2663843

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of APN1 has a stronger phenotype in mitochondrial ucDNA repair than in nuclear DNA.
    Title: Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mannan polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mannan polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Anp1p
NP_010878.1
  • Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    83050..84552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178851.1 → NP_010878.1  TPA: Anp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010878.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLL3, P32629
    UniProtKB/TrEMBL
    A0A6L0Z4R0, A6ZQR4, B3LRY1, C7GKD9, G2WCJ7, N1P7C1
    Conserved Domains (1) summary
    pfam03452
    Location:61 → 323
    Anp1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32629.3

Gene LinkOut

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