FAA2 medium-chain fatty acid-CoA ligase FAA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FAA2
Official Full Name: medium-chain fatty acid-CoA ligase FAA2
Primary source: SGD:S000000817
Locus tag: YER015W
See related: AllianceGenome:SGD:S000000817; FungiDB:YER015W; VEuPathDB:YER015W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FAM1
Summary: Enables long-chain fatty acid-CoA ligase activity; medium-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in peroxisome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to several human genes including ACSL1 (acyl-CoA synthetase long chain family member 1) and ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FAA2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (184541..186775)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CoA-ligase activity	IEA Inferred from Electronic Annotation more info
enables decanoate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocarboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: medium-chain fatty acid-CoA ligase FAA2

NP_010931.3

EC 6.2.1.3

Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

184541..186775

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178906.3 → NP_010931.3 TPA: medium-chain fatty acid-CoA ligase FAA2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010931.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLR3, P39518

UniProtKB/TrEMBL

A6ZQW3, B3LS27, C8Z716

Conserved Domains (1) summary

cd05927
Location:126 → 734

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)