BIM1 microtubule-binding protein BIM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: BIM1
Gene description: microtubule-binding protein BIM1
Primary source: FungiDB:YER016W
Locus tag: YER016W
See related: SGD:S000000818; AllianceGenome:SGD:S000000818; VEuPathDB:YER016W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YEB1
Summary: Enables microtubule plus-end binding activity. Involved in several processes, including 2-micrometer plasmid partitioning; mitotic spindle orientation checkpoint signaling; and regulation of microtubule polymerization or depolymerization. Located in microtubule cytoskeleton. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to several human genes including MAPRE1 (microtubule associated protein RP/EB family member 1) and MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See BIM1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (188277..189311)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivalency ensures persistence of a +TIP body at specialized microtubule ends.
Title: Multivalency ensures persistence of a +TIP body at specialized microtubule ends.
Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
Title: Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation.
Title: The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation.
Structure-function relationship of the Bik1-Bim1 complex has been reported.
Title: Structure-Function Relationship of the Bik1-Bim1 Complex.
the microtubule-associated proteins Bik1 and Bim1 are important host factors in the process of plasmid localization to a certain sub-nuclear locale probably assisted by the motor protein, Kip1 and microtubules, perhaps by acting as an adapter between the plasmid and the motor and thus helping to anchor the plasmid to microtubules.
Title: Microtubule-associated proteins, Bik1 and Bim1, are required for faithful partitioning of the endogenous 2 micron plasmids in budding yeast.
Bim1p has a role in maintaining a stable interpolar microtuble (ipMT) overlap zone by promoting polymerization of ipMTs during anaphase.
Title: The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle.
Crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces, are reported.
Title: Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Overproduction of Bim1, but not Kar9, restores Kar9-dependent spindle positioning in the tub4-delta dsyl mutant, reduces cortical dwelling, and promotes Bim1-Kar9 interactions.
Title: Gamma-tubulin is required for proper recruitment and assembly of Kar9-Bim1 complexes in budding yeast.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 2-micrometer plasmid partitioning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 2-micrometer plasmid partitioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle orientation checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to microtubule plus-end	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: microtubule-binding protein BIM1

NP_010932.1

Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

188277..189311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178907.1 → NP_010932.1 TPA: microtubule-binding protein BIM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010932.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLR4, P40013

UniProtKB/TrEMBL

A0A8H8ULM7, A6ZQW4, B3LS28, C7GKJ4, C8Z717, G2WCP8, N1P3X9

Conserved Domains (1) summary

COG5217
Location:1 → 342

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]