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GAL83 Gal83p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856749, updated on 2-Nov-2024

Summary

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Official Symbol
GAL83
Official Full Name
Gal83p
Primary source
SGD:S000000829
Locus tag
YER027C
See related
AllianceGenome:SGD:S000000829; FungiDB:YER027C; VEuPathDB:YER027C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPM1
Summary
Contributes to AMP-activated protein kinase activity. Involved in several processes, including cell adhesion; invasive growth in response to glucose limitation; and regulation of protein-containing complex assembly. Located in cytoplasm and nuclear envelope lumen. Part of nucleotide-activated protein kinase complex. Orthologous to several human genes including PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GAL83 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (208979..210232, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene CDP-diacylglycerol-serine O-phosphatidyltransferase Neighboring gene Mig3p Neighboring gene mRNA splicing protein SMB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multi-omic characterization of laboratory-evolved Saccharomyces cerevisiae HJ7-14 with high ability of algae-based ethanol production. Kim SJ, et al. Appl Microbiol Biotechnol, 2018 Oct. PMID 30121750
  2. SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. Mylin LM, et al. Genetics, 1994 Jul. PMID 8088514, Free PMC Article
  3. Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Wiatrowski HA, et al. Mol Cell Biol, 2004 Jan. PMID 14673168, Free PMC Article
  4. Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae. Matsumoto K, et al. J Bacteriol, 1983 Mar. PMID 6337998, Free PMC Article
  5. The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Zhang J, et al. Mol Microbiol, 2010 Jul. PMID 20545859

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Gal83, the most abundant beta subunit of the AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 (Snf1) complex, plays a major role in SNF1-mediated downregulation of the unfolded protein response (UPR) pathway.
    Title: Expression control of the AMPK regulatory subunit and its functional significance in yeast ER stress response.
  2. Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform
    Title: Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform.
  3. Gal83 is the most important isoform not only for the growth on non-fermentable carbon sources, but also for regulation of ergosterol biosynthetic genes.
    Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.
  4. catalytically inactive Snf1 promotes the cytoplasmic retention of Gal83 in glucose-grown cells through its interaction with the C terminus of Gal83
    Title: Regulation of the nucleocytoplasmic distribution of Snf1-Gal83 protein kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to AMP-activated protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein-containing complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gal83p
NP_010944.1
  • One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    208979..210232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178918.1 → NP_010944.1  TPA: Gal83p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS6, Q04739
    UniProtKB/TrEMBL
    G2WCR0, N1P7I9
    Conserved Domains (2) summary
    smart01010
    Location:306 → 416
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:163 → 247
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04739.1

Gene LinkOut

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