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CAJ1 Caj1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856772, updated on 28-Oct-2024

Summary

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Official Symbol
CAJ1
Official Full Name
Caj1p
Primary source
SGD:S000000850
Locus tag
YER048C
See related
AllianceGenome:SGD:S000000850; FungiDB:YER048C; VEuPathDB:YER048C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in protein folding and protein import into peroxisome matrix. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CAJ1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (246982..248157, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Spo73p Neighboring gene putative AAA family ATPase SAP1 Neighboring gene tRNA-Gln Neighboring gene Isd11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of CAJ1, a novel yeast homolog of dnaJ. Mukai H, et al. Gene, 1994 Jul 22. PMID 8045411
  2. Dosage sensitivity of JDPs, a valuable tool for understanding their function: a case study on Caj1 overexpression-mediated filamentous growth in budding yeast. Sagarika P, et al. Curr Genet, 2021 Jun. PMID 33492464
  3. Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1. Dobriyal N, et al. Cell Stress Chaperones, 2017 May. PMID 28261750, Free PMC Article
  4. Nanodisc-Based Proteomics Identify Caj1 as an Hsp40 with Affinity for Phosphatidic Acid Lipids. Zhang XX, et al. J Proteome Res, 2021 Oct 1. PMID 34519218
  5. Multicopy suppression screening of Saccharomyces cerevisiae Identifies the ubiquitination machinery as a main target for improving growth at low temperatures. Hernández-López MJ, et al. Appl Environ Microbiol, 2011 Nov. PMID 21908639, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nanodisc-Based Proteomics Identify Caj1 as an Hsp40 with Affinity for Phosphatidic Acid Lipids.
    Title: Nanodisc-Based Proteomics Identify Caj1 as an Hsp40 with Affinity for Phosphatidic Acid Lipids.
  2. Dosage sensitivity of JDPs, a valuable tool for understanding their function: a case study on Caj1 overexpression-mediated filamentous growth in budding yeast.
    Title: Dosage sensitivity of JDPs, a valuable tool for understanding their function: a case study on Caj1 overexpression-mediated filamentous growth in budding yeast.
  3. Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
    Title: Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Caj1p
NP_010967.3
  • Nuclear type II J heat shock protein of the E. coli dnaJ family; overexpression stabilizes amino acid permeases; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    246982..248157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178939.3 → NP_010967.3  TPA: Caj1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010967.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLU9, P39101
    UniProtKB/TrEMBL
    A6ZQZ8, B3LS61, B5VHI0, C7GSJ6, C8Z751, G2WCT2, N1P4U2
    Conserved Domains (2) summary
    COG0484
    Location:2 → 98
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam14308
    Location:176 → 376
    DnaJ-X; X-domain of DnaJ-containing
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39101.1

Gene LinkOut

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