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HMF1 putative isoleucine biosynthesis protein HMF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856785, updated on 17-May-2024

Summary

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Gene symbol
HMF1
Gene description
putative isoleucine biosynthesis protein HMF1
Primary source
FungiDB:YER057C
Locus tag
YER057C
See related
SGD:S000000859; AllianceGenome:SGD:S000000859; VEuPathDB:YER057C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HIG1
Summary
Predicted to enable deaminase activity. Predicted to be involved in organonitrogen compound catabolic process. Located in cytosol; mitochondrial intermembrane space; and nucleus. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HMF1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (270737..271126, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene purine-cytosine permease Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene Pet117p Neighboring gene Pcl6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family. Parsons L, et al. Biochemistry, 2003 Jan 14. PMID 12515541
  2. X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Deaconescu AM, et al. Proteins, 2002 Aug 1. PMID 12112709
  3. Bacterial proteins predisposed for targeting to mitochondria. Lucattini R, et al. Mol Biol Evol, 2004 Apr. PMID 14739247
  4. A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. Kim JM, et al. Genes Cells, 2001 Jun. PMID 11442631
  5. Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Oxelmark E, et al. Mol Cell Biol, 2000 Oct. PMID 11003673, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in organonitrogen compound catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative isoleucine biosynthesis protein HMF1
NP_010978.3
  • Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    270737..271126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178948.3 → NP_010978.3  TPA: putative isoleucine biosynthesis protein HMF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010978.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLW1, P40037
    UniProtKB/TrEMBL
    A0A6A5PYE4, A6ZR10, B3LS72, C7GWJ0, C8Z763, G2WCU4, N1PA41
    Conserved Domains (1) summary
    TIGR00004
    Location:24 → 127
    TIGR00004; reactive intermediate/imine deaminase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40037.1

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