TDA2 Tda2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TDA2
Official Full Name: Tda2p
Primary source: SGD:S000000873
Locus tag: YER071C
See related: AllianceGenome:SGD:S000000873; FungiDB:YER071C; VEuPathDB:YER071C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to actin filament binding activity. Involved in negative regulation of actin filament polymerization. Located in actin cortical patch. Part of Aim21-Tda2 complex. [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
Title: The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
Aim21/Tda2 functions to reduce barbed end actin assembly. Loss of the cortical patch protein Aim21 suppresses the growth defect of tpm1 cells.
Title: Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
Tda2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast.
Title: Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to actin filament binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of actin filament polymerization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Aim21-Tda2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mating projection tip	HDA more info	PubMed

NP_010994.3

Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele

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The following sections contain reference sequences that belong to a specific genome build. Explain