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DSE1 Dse1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856861, updated on 18-Sep-2024

Summary

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Official Symbol
DSE1
Official Full Name
Dse1p
Primary source
SGD:S000000926
Locus tag
YER124C
See related
AllianceGenome:SGD:S000000926; FungiDB:YER124C; VEuPathDB:YER124C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables G-protein beta/gamma-subunit complex binding activity. Involved in invasive growth in response to glucose limitation; regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; and septum digestion after cytokinesis. Located in cellular bud neck. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DSE1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (407342..409063, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase-activating protein Neighboring gene casein kinase YCK3 Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene rRNA-processing protein NSA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deregulation of DSE1 gene expression results in aberrant budding within the birth scar and cell wall integrity pathway activation in Saccharomyces cerevisiae. Frydlová I, et al. Eukaryot Cell, 2009 Apr. PMID 19252124, Free PMC Article
  2. Dse1 may control cross talk between the pheromone and filamentation pathways in yeast. Draper E, et al. Curr Genet, 2009 Dec. PMID 19820940
  3. Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. Ufano S, et al. J Cell Sci, 2004 Feb 1. PMID 14709718
  4. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Doolin MT, et al. Mol Microbiol, 2001 Apr. PMID 11309124
  5. Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation. Ismael A, et al. Sci Signal, 2016 Apr 12. PMID 27072657, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DSE1 binds both to a Gbetagamma-affinity column & to the shared MEKK, Ste11. The interaction of Dse1 with both Gbeta and Ste11 may be designed to control cross talk between the pheromone and filamentation pathways.
    Title: Dse1 may control cross talk between the pheromone and filamentation pathways in yeast.
  2. Deletion of the DSE1 gene suppressed cell wall integrity pathway and resulted in aberrant budding.
    Title: Deregulation of DSE1 gene expression results in aberrant budding within the birth scar and cell wall integrity pathway activation in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septum digestion after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dse1p
NP_011050.3
  • Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    407342..409063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179014.3 → NP_011050.3  TPA: Dse1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011050.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM30, P40077
    UniProtKB/TrEMBL
    B3LRP0
    Conserved Domains (1) summary
    sd00039
    Location:217 → 252
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40077.1

Gene LinkOut

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