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EMP65 Emp65p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856883, updated on 18-Sep-2024

Summary

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Official Symbol
EMP65
Official Full Name
Emp65p
Primary source
SGD:S000000942
Locus tag
YER140W
See related
AllianceGenome:SGD:S000000942; FungiDB:YER140W; VEuPathDB:YER140W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein folding in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EMP65 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (451565..453235)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II subunit B1 CTD phosphatase RTR1 Neighboring gene Cox15p Neighboring gene DNA-3-methyladenine glycosylase II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Zhang S, et al. Cell, 2017 Oct 5. PMID 28919078
  2. Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Vazquez HM, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165136, Free PMC Article
  3. Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. Friederichs JM, et al. G3 (Bethesda), 2012 Dec. PMID 23275891, Free PMC Article
  4. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding in endoplasmic reticulum HGI PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emp65p
NP_011067.3
  • Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    451565..453235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179030.3 → NP_011067.3  TPA: Emp65p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011067.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM47, P40085
    UniProtKB/TrEMBL
    A6ZR97, B3LRQ3, C7GQ56, C8Z7G0, G2WD27, N1PA59
    Conserved Domains (1) summary
    pfam05346
    Location:143 → 455
    DUF747; Eukaryotic membrane protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40085.1

Gene LinkOut

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