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COX15 Cox15p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856884, updated on 29-Jun-2024

Summary

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Gene symbol
COX15
Gene description
Cox15p
Primary source
FungiDB:YER141W
Locus tag
YER141W
See related
SGD:S000000943; AllianceGenome:SGD:S000000943; VEuPathDB:YER141W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in heme A biosynthetic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 2; and hypertrophic cardiomyopathy. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See COX15 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (453459..454919)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit B1 CTD phosphatase RTR1 Neighboring gene Emp65p Neighboring gene DNA-3-methyladenine glycosylase II Neighboring gene Ddi1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase. Glerum DM, et al. J Biol Chem, 1997 Jul 25. PMID 9228094
  2. Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes. Swenson S, et al. J Biol Chem, 2016 May 6. PMID 26940873, Free PMC Article
  3. Comprehensive survey of condition-specific reproductive isolation reveals genetic incompatibility in yeast. Hou J, et al. Nat Commun, 2015 May 26. PMID 26008139, Free PMC Article
  4. The biosynthesis of heme O and heme A is not regulated by copper. Morrison MS, et al. Biochemistry, 2005 Sep 20. PMID 16156667
  5. Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals. Moraes CT, et al. Biochim Biophys Acta, 2004 Dec 6. PMID 15576047

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings reveal that Cox15 not only associates with respiratory supercomplexes, but also interacts with the cytochrome bc 1 dimer even in the absence of cytochrome c oxidase.
    Title: Cox15 interacts with the cytochrome bc(1) dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase.
  2. Shy1 does not serve as a mobile heme carrier between the heme a synthase and maturing Cox1 but rather cooperates with Cox15 for heme transfer and insertion in early assembly intermediates of cytochrome c oxidase.
    Title: The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.
  3. COX10, the physiological partner of COX15, does not share the same regulatory mechanism with COX15
    Title: Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cox15p
NP_011068.1
  • Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    453459..454919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179031.1 → NP_011068.1  TPA: Cox15p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM48, P40086
    UniProtKB/TrEMBL
    A0A6A5Q197, A6ZR98, B3LRQ4, B5VHR6, C7GQ55, C8Z7G1, G2WD28, N1P5C6
    Conserved Domains (1) summary
    cl19388
    Location:15 → 451
    COX15-CtaA; Cytochrome oxidase assembly protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40086.1

Gene LinkOut

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