U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BMH1 14-3-3 family protein BMH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856924, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
BMH1
Official Full Name
14-3-3 family protein BMH1
Primary source
SGD:S000000979
Locus tag
YER177W
See related
AllianceGenome:SGD:S000000979; FungiDB:YER177W; VEuPathDB:YER177W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APR6
Summary
Enables DNA replication origin binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and phosphoserine residue binding activity. Involved in several processes, including aggresome assembly; intracellular signal transduction; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See BMH1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (545611..546414)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA helicase Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha Neighboring gene recombinase DMC1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors. van Heusden GP, et al. FEBS Lett, 1992 May 11. PMID 1378790
  2. A 14-3-3 protein homologue is expressed in feline enteroepithelial-stages of Toxoplasma gondii. Koyama T, et al. Vet Parasitol, 2001 Mar 5. PMID 11182236
  3. Phenotypic and genotypic convergences are influenced by historical contingency and environment in yeast. Spor A, et al. Evolution, 2014 Mar. PMID 24164389, Free PMC Article
  4. 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. Xu Z, et al. J Cell Sci, 2013 Sep 15. PMID 23843611, Free PMC Article
  5. Cell-to-cell heterogeneity of phosphate gene expression in yeast is controlled by alternative transcription, 14-3-3 and Spl2. Crooijmans ME, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Jun-Jul. PMID 33971368

See all (234) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
    Title: Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
  2. 14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2.
    Title: 14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2.
  3. Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84
    Title: Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.
  4. Both Bmh1 and Bmh2 associate with the promoters of at least some of these genes. BMH2, but not BMH1, attenuates the repression of genes involved in some functions required for ribosome biogenesis. BMH2 also attenuates the activation of genes sensitive to nitrogen catabolite repression.
    Title: The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription.
  5. Here we show that the defect in glucose-repression in the absence of Ssb is due to the ability of the chaperone to bridge between the SNF1 and Glc7 complexes. Ssb performs this post-translational function in concert with the 14-3-3 protein Bmh, to which Ssb binds via its very C-terminus. Raising the intracellular concentration of Ssb or Bmh enabled Glc7 to dephosphorylate SNF1 even in the absence of Reg1
    Title: The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae.
  6. Bmh1 is required for nuclear Gln3 localization and appears to function downstream of Ure2.
    Title: General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization.
  7. Data indicate that transcription activation is regulated negatively by two redundant 14-3-3 isoforms, Bmh1 and Bmh2.
    Title: Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.
  8. Bmh1 is a spindle position checkpoint (SPOC) component that breaks Bfa1 centrosome asymmetry upon SPOC activation.
    Title: The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes.
  9. EF-hand like motif-containing domain functions as the intermediary through which the 14-3-3 protein modulates the function of the catalytic domain of Nth1
    Title: Role of the EF-hand-like motif in the 14-3-3 protein-mediated activation of yeast neutral trehalase Nth1.
  10. Bmh1 and Bmh2 inhibit transcription by binding to Adr1 at promoters that contain a preinitiation complex, demonstrating that Bmh-mediated inhibition is not due to nuclear exclusion, inhibition of DNA binding, or RNA polymerase II (Pol II) recruitment.
    Title: 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoserine residue binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in aggresome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chitin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mitotic spindle orientation checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pseudohyphal growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of glycogen metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction involved in filamentous growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
14-3-3 family protein BMH1
NP_011104.3
  • 14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    545611..546414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179067.3 → NP_011104.3  TPA: 14-3-3 family protein BMH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011104.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM86, P29311, Q06854
    UniProtKB/TrEMBL
    A6ZRD4, B3LRT7, B5VHV9, C7GS32, C8Z7K1, N1P3Q2
    Conserved Domains (1) summary
    COG5040
    Location:1 → 267
    BMH1; 14-3-3 family protein [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29311.4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools