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STK16 serine/threonine kinase 16 [ Homo sapiens (human) ]

Gene ID: 8576, updated on 28-Oct-2024

Summary

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Official Symbol
STK16provided by HGNC
Official Full Name
serine/threonine kinase 16provided by HGNC
Primary source
HGNC:HGNC:11394
See related
Ensembl:ENSG00000115661 MIM:604719; AllianceGenome:HGNC:11394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK; KRCT; MPSK; TSF1; hPSK; PKL12
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See STK16 in Genome Data Viewer
Location:
2q35
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219245479..219250337)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219730246..219735104)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220110201..220115059)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093298-220093846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220093847-220094394 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220094395-220094942 Neighboring gene ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Neighboring gene galactosidase beta 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:220109882-220110464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STK16 regulates actin dynamics to control Golgi organization and cell cycle. Liu J, et al. Sci Rep, 2017 Mar 15. PMID 28294156, Free PMC Article
  2. STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner. Peng L, et al. Mol Med, 2024 Apr 15. PMID 38622518, Free PMC Article
  3. Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase. Berson AE, et al. Biochem Biophys Res Commun, 1999 Jun 16. PMID 10364453
  4. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells. In JG, et al. Biochem J, 2014 Oct 15. PMID 25084525, Free PMC Article
  5. Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis. Wang X, et al. Cancer Sci, 2022 Mar. PMID 35092121, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.
    Title: Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.
  2. STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner.
    Title: STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner.
  3. Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis.
    Title: Exosomes from M1-polarized macrophages promote apoptosis in lung adenocarcinoma via the miR-181a-5p/ETS1/STK16 axis.
  4. we revealed STK16 as a novel actin binding protein that resides in the Golgi, which regulates actin dynamics to control Golgi structure and participate in cell cycle progression.
    Title: STK16 regulates actin dynamics to control Golgi organization and cell cycle.
  5. MAL2 and STK16 function to sort secretory soluble cargo into the constitutive secretory pathway in hepatocytes.
    Title: Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.
  6. The Endogenous STK16 subcellular localization was evaluated by indirect immunofluorescence in NRK cells, demonstrating a Golgi-associated pattern that appears to be independent of signals provided by integrin pathways.
    Title: Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39635, MGC16211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 16
Names
TGF-beta-stimulated factor 1
myristoylated and palmitoylated serine/threonine-protein kinase
protein kinase PKL12
protein kinase expressed in day 12 fetal liver
tyrosine-protein kinase STK16
NP_001008910.1
NP_001317142.1
NP_001317143.1
NP_001317144.1
XP_024308963.1
XP_047302096.1
XP_047302097.1
XP_054200279.1
XP_054200280.1
XP_054200281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008910.4 → NP_001008910.1  serine/threonine-protein kinase 16 isoform 1

    See identical proteins and their annotated locations for NP_001008910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    A8K9H9, O75716, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
    UniProtKB/TrEMBL
    B8ZZN3
    Related
    ENSP00000386928.3, ENST00000409638.7
    Conserved Domains (1) summary
    cd13986
    Location:19 → 295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  2. NM_001330213.2 → NP_001317142.1  serine/threonine-protein kinase 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS42822.1
    UniProtKB/Swiss-Prot
    A8K9H9, O75716, Q5U0F8, Q96KI2, Q9BUH4, Q9UEN3, Q9UP78
    UniProtKB/TrEMBL
    B8ZZN3
    Related
    ENSP00000379964.2, ENST00000396738.7
    Conserved Domains (1) summary
    cd13986
    Location:19 → 295
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  3. NM_001330214.1 → NP_001317143.1  serine/threonine-protein kinase 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068946, AK298471
    Consensus CDS
    CCDS82573.1
    UniProtKB/TrEMBL
    B8ZZI5
    Related
    ENSP00000386553.1, ENST00000409743.1
    Conserved Domains (1) summary
    cd13986
    Location:19 → 263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  4. NM_001330215.2 → NP_001317144.1  serine/threonine-protein kinase 16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068946
    Consensus CDS
    CCDS86921.1
    UniProtKB/TrEMBL
    B4DPS1
    Related
    ENSP00000386309.3, ENST00000409516.7
    Conserved Domains (1) summary
    cl21453
    Location:29 → 177
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219245479..219250337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446140.1 → XP_047302096.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5

  2. XM_024453195.2 → XP_024308963.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5
    Conserved Domains (1) summary
    cd13986
    Location:19 → 263
    STKc_16; Catalytic domain of Serine/Threonine Kinase 16

  3. XM_047446141.1 → XP_047302097.1  serine/threonine-protein kinase 16 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219730246..219735104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344304.1 → XP_054200279.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5

  2. XM_054344305.1 → XP_054200280.1  serine/threonine-protein kinase 16 isoform X1

    UniProtKB/TrEMBL
    B8ZZI5

  3. XM_054344306.1 → XP_054200281.1  serine/threonine-protein kinase 16 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003691.2: Suppressed sequence

    Description
    NM_003691.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_032768.1: Suppressed sequence

    Description
    NM_032768.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75716.4 GenPept UniProtKB/Swiss-Prot:O75716

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