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GTPBP10 GTP binding protein 10 [ Homo sapiens (human) ]

Gene ID: 85865, updated on 5-Mar-2024

Summary

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Official Symbol
GTPBP10provided by HGNC
Official Full Name
GTP binding protein 10provided by HGNC
Primary source
HGNC:HGNC:25106
See related
Ensembl:ENSG00000105793 MIM:610920; AllianceGenome:HGNC:25106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ObgH2; UG0751c10
Summary
Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), kidney (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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See GTPBP10 in Genome Data Viewer
Location:
7q21.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (90346716..90391453)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (91595008..91639742)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (89976030..90020767)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 69 Neighboring gene family with sequence similarity 237 member B Neighboring gene uncharacterized LOC107986715 Neighboring gene uncharacterized LOC101927446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26245 Neighboring gene cell division cycle 42 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90032955-90033480 Neighboring gene claudin 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human GTPBP10 is required for mitoribosome maturation. Maiti P, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321378, Free PMC Article
  2. The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Lavdovskaia E, et al. Nucleic Acids Res, 2018 Sep 19. PMID 30085210, Free PMC Article
  3. Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. Hirano Y, et al. Genes Cells, 2006 Nov. PMID 17054726
  4. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Arroyo JD, et al. Cell Metab, 2016 Dec 13. PMID 27667664, Free PMC Article
  5. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. van Meurs JB, et al. Am J Clin Nutr, 2013 Sep. PMID 23824729, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GTPBP10 primarily ensures proper mtLSU maturation and ultimately serves to coordinate mtSSU and mtLSU accumulation
    Title: Human GTPBP10 is required for mitoribosome maturation.
  2. Our results suggest that GTPBP10 is a ribosome biogenesis factor of the mtLSU required for late stages of maturation.
    Title: The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.
  3. Knock-down of ObgH1 by RNAi induced mitochondria elongation, whereas knock-down of ObgH2 resulted in the disorganization of the nucleolar architecture.
    Title: Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38242, MGC104191, DKFZp686A10121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding HDA PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTP-binding protein 10
Names
GTP binding protein 10 (putative)
protein obg homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042717.3 → NP_001036182.1  GTP-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001036182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks alternate in-frame exons in the 5' coding region, compared to variant 2. The resulting protein (isoform 1) is shorter when it is compared to isoform 2.
    Source sequence(s)
    AC006153, AK095561, AK125553, AK294325, T65158
    Consensus CDS
    CCDS43614.1
    UniProtKB/Swiss-Prot
    A4D1E9
    Related
    ENSP00000257659.8, ENST00000257659.12
    Conserved Domains (2) summary
    cd01898
    Location:77 → 264
    Obg; Obg GTPase
    TIGR00231
    Location:77 → 262
    small_GTP; small GTP-binding protein domain

  2. NM_033107.4 → NP_149098.2  GTP-binding protein 10 isoform 2

    See identical proteins and their annotated locations for NP_149098.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and it encodes the longer protein (isoform 2)
    Source sequence(s)
    AC002064, AC006153, AK095561, AK125553, AK294325, T65158
    Consensus CDS
    CCDS5617.1
    UniProtKB/Swiss-Prot
    A4D1E9, B4DFY6, Q3B7A6, Q5H9V2, Q8IXG8, Q8N982, Q8WU16, Q9BSP1, Q9Y6T6
    Related
    ENSP00000222511.7, ENST00000222511.11
    Conserved Domains (1) summary
    TIGR02729
    Location:25 → 337
    Obg_CgtA; Obg family GTPase CgtA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    90346716..90391453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    91595008..91639742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4D1E9.1 GenPept UniProtKB/Swiss-Prot:A4D1E9

Gene LinkOut

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