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dhcA cytoplasmic dynein heavy chain [ Dictyostelium discoideum AX4 ]

Gene ID: 8620457, updated on 18-Sep-2024

Summary

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Official Symbol
dhcA
Official Full Name
cytoplasmic dynein heavy chain
Primary source
dictyBase:DDB_G0276355
Locus tag
DDB_G0276355
See related
AmoebaDB:DDB_G0276355; VEuPathDB:DDB_G0276355
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0166999; DDBDRAFT_0185096; DDB_0166999; DDB_0185096
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Genomic context

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Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_007088.5 (6681538..6695830, complement)

Chromosome 2 - NC_007088.5Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene N-acetyltransferase 5 Neighboring gene microtubule interacting and transport domain-containing protein Neighboring gene FNIP repeat-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007088.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C-sequence of the Dictyostelium cytoplasmic dynein participates in processivity modulation. Numata N, et al. FEBS Lett, 2011 Apr 20. PMID 21420957
  2. Identification and immunolocalization of cytoplasmic dynein in Dictyostelium. Koonce MP, et al. Cell Motil Cytoskeleton, 1990. PMID 2153057
  3. Molecular characterization of a cytoplasmic dynein from Dictyostelium. Koonce MP, et al. J Eukaryot Microbiol, 1994 Nov-Dec. PMID 7866389
  4. Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein. Kon T, et al. Biochemistry, 2004 Sep 7. PMID 15366936
  5. Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein. Mogami T, et al. J Biol Chem, 2007 Jul 27. PMID 17548361

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest a potential function of the cytoplasmic dynein distal C-sequence segment as a modulator of processivity.
    Title: C-sequence of the Dictyostelium cytoplasmic dynein participates in processivity modulation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables CTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in minus-end-directed vesicle transport along microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagosome maturation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ATPase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in early phagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in phagolysosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic dynein heavy chain
Names
dynein beta chain, flagellar outer arm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007088.5 Reference assembly

    Range
    6681538..6695830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_638093.1 → XP_643185.1  cytoplasmic dynein heavy chain [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_643185.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P34036, Q551T4, Q8T128
    Conserved Domains (7) summary
    COG5245
    Location:1079 → 4415
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:4015 → 4717
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:288 → 866
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1390 → 1789
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3285 → 3618
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3646 → 3861
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1936 → 2164
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version

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