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pikA phosphatidylinositol-4,5-diphosphate 3-kinase [ Dictyostelium discoideum AX4 ]

Gene ID: 8621687, updated on 18-Sep-2024

Summary

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Official Symbol
pikA
Official Full Name
phosphatidylinositol-4,5-diphosphate 3-kinase
Primary source
dictyBase:DDB_G0278727
Locus tag
DDB_G0278727
See related
AmoebaDB:DDB_G0278727; VEuPathDB:DDB_G0278727
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0206183; DDBDRAFT_0214949; DDB_0206183; DDB_0214949
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Genomic context

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Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_007089.4 (1154369..1159209)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene major sperm protein domain-containing protein Neighboring gene ubiquitin-conjugating enzyme E2 Neighboring gene hypothetical protein Neighboring gene GDT family protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Arai Y, et al. Proc Natl Acad Sci U S A, 2010 Jul 6. PMID 20562345, Free PMC Article
  2. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Loovers HM, et al. Mol Biol Cell, 2006 Apr. PMID 16421252, Free PMC Article
  3. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization. Buczynski G, et al. J Cell Biol, 1997 Mar 24. PMID 9087443, Free PMC Article
  4. Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. Zhou K, et al. J Cell Sci, 1998 Jan. PMID 9405319
  5. Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors. Tariqul Islam AFM, et al. Mol Cell Biochem, 2019 Jul. PMID 30879206, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to adenylate cyclase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within asexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bleb assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within macropinocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phagolysosome assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phagosome maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of macropinocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pseudopodium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cAMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to caffeine IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol-4,5-diphosphate 3-kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    1154369..1159209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_636863.1 → XP_641955.1  phosphatidylinositol-4,5-diphosphate 3-kinase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_641955.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P54673, Q54XS5
    Conserved Domains (4) summary
    cd08380
    Location:846 → 1023
    C2_PI3K_like; C2 domain present in phosphatidylinositol 3-kinases (PI3Ks)
    cd00872
    Location:1048 → 1218
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00891
    Location:1221 → 1555
    PI3Kc; Catalytic domain of Phosphoinositide 3-kinase
    pfam00794
    Location:688 → 792
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
Heading Accession and Version

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