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tgrC1 IPT/TIG domain-containing protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8622682, updated on 17-May-2024

Summary

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Gene symbol
tgrC1
Gene description
IPT/TIG domain-containing protein
Primary source
dictyBase:DDB_G0280531
Locus tag
DDB_G0280531
See related
AmoebaDB:DDB_G0280531; VEuPathDB:DDB_G0280531
Gene type
protein coding
RNA name
signal protein
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0206125; DDBDRAFT_0214927; DDB_0206125; DDB_0214927
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Genomic context

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Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_007089.4 (3630672..3633406, complement)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene IPT/TIG domain-containing protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development. Wang J, et al. Dev Biol, 2000 Nov 15. PMID 11071787
  2. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Dynes JL, et al. Genes Dev, 1994 Apr 15. PMID 7926779
  3. A glycoprotein involved in aggregation of D. discoideum is distributed on the cell surface in a nonrandom fashion favoring cell junctions. Geltosky JE, et al. Cell, 1980 Sep. PMID 7407916
  4. Purification and partial characterization of a cell adhesion molecule (gp150) involved in postaggregation stage cell-cell binding in Dictyostelium discoideum. Gao EN, et al. J Biol Chem, 1992 May 5. PMID 1577768
  5. Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Geltosky JE, et al. Cell, 1979 Oct. PMID 498273

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. compatibility of the allotype encoded by the tgrB1 and tgrC1 genes is required for tissue integration, as manifested in cell polarization, coordinated movement and differentiation into prestalk and prespore cells
    Title: Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.
  2. TgrC1 is a cell adhesion glycoprotein with distinct Functions in Dictyostelium development and allorecognition
    Title: TgrC1 Has Distinct Functions in Dictyostelium Development and Allorecognition.
  3. The authors engineered syngeneic cheaters and victims that differed only in their kin-recognition genes, tgrB1 and tgrC1, and in a single cheater allele and found that the victims escaped exploitation by different types of nonkin cheaters.
    Title: Kin recognition protects cooperators against cheaters.
  4. Use of recombinant TgrC1 and TgrB1 proteins in binding assays demonstrates how the IPT/TIG domains in these two cell adhesion molecules participate directly in protein-protein interactions to mediate cell-cell adhesion.
    Title: TgrC1 mediates cell-cell adhesion by interacting with TgrB1 via mutual IPT/TIG domains during development of Dictyostelium discoideum.
  5. findings show a matching pair of tgrB1 and tgrC1 alleles is necessary and sufficient for attractive self-recognition, which is mediated by differential cell-cell adhesion; propose that TgrB1 and TgrC1 proteins mediate this adhesion through direct binding
    Title: Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aggregation involved in sorocarp development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in altruistic, chimeric sorocarp development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell self recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to catechin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in socially cooperative development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp stalk cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of protein complex involved in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
IPT/TIG domain-containing protein
cell adhesion molecule
signal protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    3630672..3633406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_636031.1 → XP_641123.1  signal protein [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_641123.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P42523, Q54V08
    UniProtKB/TrEMBL
    C0JMN1, C0JMN6, C0JMP8
    Conserved Domains (1) summary
    cd00603
    Location:294 → 380
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q54V08.1

Gene LinkOut

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Molecular Biology Databases
Research Materials