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rasC Ras GTPase [ Dictyostelium discoideum AX4 ]

Gene ID: 8623068, updated on 18-Sep-2024

Summary

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Official Symbol
rasC
Official Full Name
Ras GTPase
Primary source
dictyBase:DDB_G0281385
Locus tag
DDB_G0281385
See related
AmoebaDB:DDB_G0281385; VEuPathDB:DDB_G0281385
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0205589; DDBDRAFT_0214827; DDB_0205589; DDB_0214827
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_007089.4 (4519070..4520084)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene DUF544 family protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis. Lim CJ, et al. Exp Cell Res, 2005 May 15. PMID 15878331
  2. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. Cai H, et al. J Cell Biol, 2010 Jul 26. PMID 20660630, Free PMC Article
  3. Determinants of RasC specificity during Dictyostelium aggregation. Bolourani P, et al. J Biol Chem, 2010 Dec 31. PMID 20971846, Free PMC Article
  4. Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling. Senoo H, et al. Cell Rep, 2020 Nov 24. PMID 33238110, Free PMC Article
  5. Chemoattractant-induced Ras activation during Dictyostelium aggregation. Kae H, et al. EMBO Rep, 2004 Jun. PMID 15143344, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual Ras/Rap1 regulation of TORC2 may allow for integration of Ras and Rap1 signaling pathways in directed cell migration.
    Title: The small GTPases Ras and Rap1 bind to and control TORC2 activity.
  2. RasC plays a role in motility and pinocytosis.
    Title: Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis.
  3. analysis of RasC specificity determinants during Dictyostelium aggregation
    Title: Determinants of RasC specificity during Dictyostelium aggregation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables G protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables TORC2 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanylate cyclase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanylate cyclase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled chemorepellent receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within asexual reproduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to cGMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to folate IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to folate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral pseudopodium retraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of asexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within polyphosphate-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC2 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of positive chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein heterooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to folic acid IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell leading edge IC
Inferred by Curator
more info
 PubMed 
located_in lipid droplet HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ras GTPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    4519070..4520084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_635591.1 → XP_640683.1  Ras GTPase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_640683.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32253, Q54TX8
    Conserved Domains (2) summary
    cd04138
    Location:5 → 167
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:6 → 169
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein
Heading Accession and Version

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Research Materials