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acaA adenylate cyclase [ Dictyostelium discoideum AX4 ]

Gene ID: 8623247, updated on 18-Sep-2024

Summary

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Official Symbol
acaA
Official Full Name
adenylate cyclase
Primary source
dictyBase:DDB_G0281545
Locus tag
DDB_G0281545
See related
AmoebaDB:DDB_G0281545; VEuPathDB:DDB_G0281545
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0214814; DDBDRAFT_0218330; DDB_0214814; DDB_0218330
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Genomic context

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Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_007089.4 (4958602..4963128)

Chromosome 3 - NC_007089.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene LSM domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007089.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium. Wang W, et al. J Cell Sci, 2018 May 4. PMID 29618632, Free PMC Article
  2. The effect of divalent cations on aggregation of Dictyostelium discoideum. Loomis WF, et al. Differentiation, 1978. PMID 108168
  3. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Pitt GS, et al. Cell, 1992 Apr 17. PMID 1348970
  4. Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxis. Stepanovic V, et al. Eukaryot Cell, 2005 Apr. PMID 15821137, Free PMC Article
  5. Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge. Kriebel PW, et al. J Cell Biol, 2008 Dec 1. PMID 19047467, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data show that the more widely expressed DgcA activates tip-expressed ACA, which then acts on PKA to induce stalk genes. These results explain why stalk formation always initiates at the site of the morphogenetic organizer.
    Title: Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer.
  2. Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene.
    Title: Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within c-di-GMP signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lateral pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sorocarp stalk cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-C IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to caffeine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to catechin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to curcumin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to imidacloprid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to manganese ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sporulation resulting in formation of a cellular spore IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell trailing edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell trailing edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in uropod IEA
Inferred from Electronic Annotation
more info
  
is_active_in uropod membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in uropod membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase
Names
adenylyl cyclase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007089.4 Reference assembly

    Range
    4958602..4963128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_635544.2 → XP_640636.2  adenylyl cyclase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_640636.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q03100, Q54TF5
    Conserved Domains (3) summary
    cd07302
    Location:438 → 674
    CHD; cyclase homology domain
    smart00044
    Location:1144 → 1334
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1180 → 1356
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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