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pkaC PKA family protein kinase [ Dictyostelium discoideum AX4 ]

Gene ID: 8624359, updated on 17-May-2024

Summary

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Gene symbol
pkaC
Gene description
PKA family protein kinase
Primary source
dictyBase:DDB_G0283907
Locus tag
DDB_G0283907
See related
AmoebaDB:DDB_G0283907; VEuPathDB:DDB_G0283907
Gene type
protein coding
RNA name
cAMP-dependent protein kinase
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0185782; DDBDRAFT_0215408; DDB_0185782; DDB_0215408
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Genomic context

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Location:
chromosome: 4
Exon count:
2
Sequence:
Chromosome: 4; NC_007090.3 (1394958..1397005)

Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene ERK subfamily protein kinase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007090.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypertonic signal promotes stability of Dictyostelium spores via a PKA-independent pathway. Yamada Y, et al. FEMS Microbiol Lett, 2003 Dec 12. PMID 14680693
  2. Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation. Escalante R, et al. Mech Dev, 2002 Sep. PMID 12204259
  3. Interaction of gdt1 and protein kinase A (PKA) in the growth-differentiation-transition in Dictyostelium. Zeng C, et al. Differentiation, 2001 Feb. PMID 11270120
  4. Role of cAMP-dependent protein kinase during growth and early development of Dictyostelium discoideum. Primpke G, et al. Dev Biol, 2000 May 1. PMID 10772794
  5. A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium. Laub MT, et al. Mol Biol Cell, 1998 Dec. PMID 9843585, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IC
Inferred by Curator
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled chemorepellent receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in c-di-GMP signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within culmination involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity regulating cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oscillatory cAMP signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sorocarp spore cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sorocarp stalk cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of sorocarp stalk cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to curcumin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to curcumin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp spore cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Names
PKA family protein kinase
cAMP-dependent protein kinase
protein kinase A catalytic subunit
protein kinase, AGC group
protein serine/threonine kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007090.3 Reference assembly

    Range
    1394958..1397005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_633743.1 → XP_638835.1  cAMP-dependent protein kinase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_638835.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P34099, Q54QA9
    Conserved Domains (2) summary
    PTZ00263
    Location:332 → 633
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd05580
    Location:334 → 623
    STKc_PKA_like; Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q54QA9.1

Gene LinkOut

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Molecular Biology Databases
Research Materials