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myoB class I myosin [ Dictyostelium discoideum AX4 ]

Gene ID: 8626983, updated on 18-Sep-2024

Summary

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Official Symbol
myoB
Official Full Name
class I myosin
Primary source
dictyBase:DDB_G0289117
Locus tag
DDB_G0289117
See related
AmoebaDB:DDB_G0289117; VEuPathDB:DDB_G0289117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0188280; DDBDRAFT_0191351; DDB_0188280; DDB_0191351
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Genomic context

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Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_007091.3 (2410248..2413925)

Chromosome 5 - NC_007091.3Genomic Context describing neighboring genes Neighboring gene cAMP-specific phosphodiesterase Neighboring gene hypothetical protein Neighboring gene cAMP phosphodiesterase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007091.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis of dynamic relocalization of Dictyostelium myosin IB. Brzeska H, et al. J Biol Chem, 2012 Apr 27. PMID 22367211, Free PMC Article
  2. Myosin I overexpression impairs cell migration. Novak KD, et al. J Cell Biol, 1997 Feb 10. PMID 9024693, Free PMC Article
  3. The myosin I SH3 domain and TEDS rule phosphorylation site are required for in vivo function. Novak KD, et al. Mol Biol Cell, 1998 Jan. PMID 9436992, Free PMC Article
  4. Mechanism, regulation, and functional properties of Dictyostelium myosin-1B. Tsiavaliaris G, et al. J Biol Chem, 2008 Feb 22. PMID 18089562
  5. The GPQ-rich segment of Dictyostelium myosin IB contains an actin binding site. Rosenfeld SS, et al. Biochemistry, 1994 Mar 1. PMID 8117689

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin light chain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin-myosin filament sliding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular component assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within exocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within filopodium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lateral pseudopodium retraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagosome reneutralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pinocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of post-lysosomal vacuole size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to differentiation-inducing factor 1 HDA PubMed 
acts_upstream_of_or_within response to other organism TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin wave IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin-based cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actomyosin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in leading edge of lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in macropinocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in macropinocytic cup cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic cup lip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
class I myosin
Names
myosin IB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007091.3 Reference assembly

    Range
    2410248..2413925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_631290.1 → XP_636382.1  myosin IB [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_636382.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P34092, Q54HY1
    Conserved Domains (5) summary
    smart00242
    Location:8 → 691
    MYSc; Myosin. Large ATPases
    smart00326
    Location:1054 → 1109
    SH3; Src homology 3 domains
    cd01378
    Location:23 → 678
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:718 → 893
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl09930
    Location:977 → 1012
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
Nucleotide Protein
Heading Accession and Version

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