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rasG Ras GTPase [ Dictyostelium discoideum AX4 ]

Gene ID: 8629223, updated on 18-Sep-2024

Summary

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Official Symbol
rasG
Official Full Name
Ras GTPase
Primary source
dictyBase:DDB_G0293434
Locus tag
DDB_G0293434
See related
AmoebaDB:DDB_G0293434; VEuPathDB:DDB_G0293434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0191937; DDBDRAFT_0201663; DDB_0191937; DDB_0201663
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Genomic context

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Location:
chromosome: 6
Exon count:
2
Sequence:
Chromosome: 6; NC_007092.3 (2877682..2878372, complement)

Chromosome 6 - NC_007092.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ABC transporter A family protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007092.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG. Secko DM, et al. Proteomics, 2004 Sep. PMID 15352238
  2. Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium. Kosaka C, et al. Biochim Biophys Acta, 1998 Mar 12. PMID 9551080
  3. Ras-related genes in Dictyostelium discoideum. Robbins SM, et al. Dev Genet, 1991. PMID 2049874
  4. Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. Tuxworth RI, et al. J Cell Biol, 1997 Aug 11. PMID 9245789, Free PMC Article
  5. Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development. Khosla M, et al. Mol Cell Biol, 1996 Aug. PMID 8754814, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asymmetric Ras activation in turning protrusions underscores that gradients can be sensed locally and translated into orientation. Different to cells of normal size, the polarity of large cells is not linked to an increasing front-to-tail gradient of the PIP3-phosphatase PTEN.
    Title: Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells.
  2. RasG plays a role in the early development of Dictyostelium discoideum cells through its involvement in the expression and dephosphorylation of DdCAD-1 during signal transduction.
    Title: An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1.
  3. Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.
    Title: Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables G protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanylate cyclase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol 3-kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled chemorepellent receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G protein-coupled chemorepellent receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within asexual reproduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to cGMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to folate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of sorocarp spore cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of asexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium-dependent cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization to phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to folic acid IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet HDA PubMed 
located_in macropinosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in pathogen-containing vacuole HDA PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ras GTPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007092.3 Reference assembly

    Range
    2877682..2878372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_629131.1 → XP_629133.1  Ras GTPase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_629133.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P15064, Q54BT6
    Conserved Domains (1) summary
    PTZ00369
    Location:1 → 189
    PTZ00369; Ras-like protein; Provisional
Nucleotide Protein
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