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JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough [ Homo sapiens (human) ]

Gene ID: 8681, updated on 2-Nov-2024

Summary

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Official Symbol
JMJD7-PLA2G4Bprovided by HGNC
Official Full Name
JMJD7-PLA2G4B readthroughprovided by HGNC
Primary source
HGNC:HGNC:34449
See related
Ensembl:ENSG00000168970 AllianceGenome:HGNC:34449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT16992; cPLA2-beta
Summary
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
Annotation information
Note: This geneID was previously used to represent the PLA2G4B locus; however, it is now believed that this gene represents a set of read-through transcripts from the upstream JmjC-domain containing gene (geneID: 100137047) into the separate PLA2G4B gene. Consequently, PLA2G4B is now represented by geneID:100137049. [13 Feb 2013]
Expression
Ubiquitous expression in skin (RPKM 27.8), esophagus (RPKM 12.4) and 24 other tissues See more
Orthologs
all
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Genomic context

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See JMJD7-PLA2G4B in Genome Data Viewer
Location:
15q15.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41828092..41848143)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39634005..39654098)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42120290..42140341)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9285 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:42117960-42118842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9286 Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42144871-42145480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42145481-42146091 Neighboring gene jumonji domain containing 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42147073-42147589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42147590-42148105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42148623-42149137 Neighboring gene phospholipase A2 group IVB Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene microRNA 4310

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. Tao R, et al. Am J Med Genet B Neuropsychiatr Genet, 2005 Aug 5. PMID 15999343
  2. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. Morris DW, et al. Am J Med Genet B Neuropsychiatr Genet, 2004 Aug 15. PMID 15274049
  3. Molecular characterization of cytosolic phospholipase A2-beta. Song C, et al. J Biol Chem, 1999 Jun 11. PMID 10358058
  4. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. Degousee N, et al. J Biol Chem, 2002 Feb 15. PMID 11741884
  5. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. Ghosh M, et al. J Biol Chem, 2006 Jun 16. PMID 16617059

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  3. circulating human neutrophils express groups V and X sPLA(2) (GV and GX sPLA(2)) mRNA and contain GV and GX sPLA(2) proteins, whereas GIB, GIIA, GIID, GIIE, GIIF, GIII, and GXII sPLA(2)s are undetectable
    Title: Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
JMJD7-PLA2G4B protein
Names
jumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029927.1 RefSeqGene

    Range
    5001..25064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198588.2 → NP_001185517.1  JMJD7-PLA2G4B protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as cPLA2 beta2) lacks an alternate exon resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC020659, BC013415, DA096882, DQ523799
    UniProtKB/Swiss-Prot
    P0C869
    Related
    ENSP00000342785.4, ENST00000342159.6
    Conserved Domains (3) summary
    cd04036
    Location:242 → 361
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam13621
    Location:38 → 223
    Cupin_8; Cupin-like domain
    cl11396
    Location:474 → 880
    Patatin_and_cPLA2; Patatins and Phospholipases

  2. NM_005090.4 → NP_005081.1  JMJD7-PLA2G4B protein isoform a

    See identical proteins and their annotated locations for NP_005081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as cPLA2 beta) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF065215, BI768993, BU688449, DA080158, DA096882
    UniProtKB/Swiss-Prot
    P0C869
    Related
    ENSP00000371886.4, ENST00000382448.8
    Conserved Domains (3) summary
    cd07201
    Location:474 → 999
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:242 → 361
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam13621
    Location:38 → 223
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41828092..41848143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39634005..39654098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015346.1: Suppressed sequence

    Description
    NR_015346.1: This RefSeq was permanently suppressed because it is incompletely processed.
Nucleotide Protein
Heading Accession and Version

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