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TNK1 tyrosine kinase non receptor 1 [ Homo sapiens (human) ]

Gene ID: 8711, updated on 11-Apr-2024

Summary

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Official Symbol
TNK1provided by HGNC
Official Full Name
tyrosine kinase non receptor 1provided by HGNC
Primary source
HGNC:HGNC:11940
See related
Ensembl:ENSG00000174292 MIM:608076; AllianceGenome:HGNC:11940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOS1
Summary
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues See more
Orthologs
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Genomic context

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See TNK1 in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7380047..7389742)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7285126..7293784)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7284408..7293061)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258543-7259069 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7269638-7269860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7283926-7284426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8114 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8115 Neighboring gene phospholipid scramblase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8116 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity. Ahmed S, et al. J Biol Chem, 2022 Dec. PMID 36334623, Free PMC Article
  2. Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease. Zeman T, et al. Mol Neurobiol, 2021 Mar. PMID 33070267
  3. Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock. Halbgebauer R, et al. Front Immunol, 2020. PMID 32983160, Free PMC Article
  4. High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells. Henderson MC, et al. Mol Cancer Res, 2011 Jun. PMID 21536687, Free PMC Article
  5. Identification of activated Tnk1 kinase in Hodgkin's lymphoma. Gu TL, et al. Leukemia, 2010 Apr. PMID 20090780

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
    Title: Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
  2. The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
    Title: The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
  3. Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
    Title: Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
  4. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
    Title: TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
  5. Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
    Title: Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
  6. TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut.
    Title: Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
  7. the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied.
    Title: Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.
  8. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.
    Title: Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
  9. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.
    Title: High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tyrosine kinase, non-receptor, 1 (TNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TNK1
Names
CD38 negative kinase 1
NP_001238831.1
NP_003976.2
XP_011522347.1
XP_011522348.1
XP_011522349.1
XP_011522350.1
XP_054173634.1
XP_054173635.1
XP_054173636.1
XP_054188002.1
XP_054188003.1
XP_054188004.1
XP_054188005.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251902.3 → NP_001238831.1  non-receptor tyrosine-protein kinase TNK1 isoform 1

    See identical proteins and their annotated locations for NP_001238831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS58510.1
    UniProtKB/Swiss-Prot
    O95364, Q13470, Q8IYI4
    Related
    ENSP00000459799.1, ENST00000576812.5
    Conserved Domains (6) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119 → 377
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:385 → 441
    SH3; Src homology 3 domains
    cd14328
    Location:624 → 663
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl21453
    Location:120 → 379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:594 → 637
    UBA_like_SF; UBA domain-like superfamily

  2. NM_003985.6 → NP_003976.2  non-receptor tyrosine-protein kinase TNK1 isoform 2

    See identical proteins and their annotated locations for NP_003976.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS45602.1
    UniProtKB/Swiss-Prot
    Q13470
    Related
    ENSP00000509611.1, ENST00000688331.1
    Conserved Domains (6) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119 → 377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:619 → 658
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396 → 435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:589 → 632
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7380047..7389742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524045.3 → XP_011522347.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    See identical proteins and their annotated locations for XP_011522347.1

    UniProtKB/Swiss-Prot
    Q13470
    Conserved Domains (6) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119 → 377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:619 → 658
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396 → 435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:589 → 632
    UBA_like_SF; UBA domain-like superfamily

  2. XM_011524047.4 → XP_011522349.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

    UniProtKB/TrEMBL
    G9BXQ3
    Conserved Domains (4) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119 → 377
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:396 → 435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 379
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011524046.4 → XP_011522348.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    Conserved Domains (6) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:119 → 377
    STYKc; Protein kinase; unclassified specificity
    cd14328
    Location:617 → 656
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:396 → 435
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:120 → 379
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:587 → 630
    UBA_like_SF; UBA domain-like superfamily

  4. XM_011524048.2 → XP_011522350.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

    Conserved Domains (4) summary
    cd14328
    Location:462 → 501
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cl17036
    Location:239 → 278
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:7 → 222
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:432 → 475
    UBA_like_SF; UBA domain-like superfamily

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p14 PATCHES

    Range
    504..10199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332027.1 → XP_054188002.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

  2. XM_054332029.1 → XP_054188004.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

  3. XM_054332028.1 → XP_054188003.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

  4. XM_054332030.1 → XP_054188005.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7285126..7293784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317660.1 → XP_054173635.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

  2. XM_054317659.1 → XP_054173634.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

  3. XM_054317661.1 → XP_054173636.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13470.3 GenPept UniProtKB/Swiss-Prot:Q13470

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