U.S. flag

An official website of the United States government

ADAM9 ADAM metallopeptidase domain 9 [ Homo sapiens (human) ]

Gene ID: 8754, updated on 4-Jan-2025

Summary

Official Symbol
ADAM9provided by HGNC
Official Full Name
ADAM metallopeptidase domain 9provided by HGNC
Primary source
HGNC:HGNC:216
See related
Ensembl:ENSG00000168615 MIM:602713; AllianceGenome:HGNC:216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCMP; MDC9; CORD9; Mltng
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADAM9 in Genome Data Viewer
Location:
8p11.22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38996973..39105261)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39274115..39382400)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38854492..38962780)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38771665-38772346 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38793869-38794549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38794550-38795229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27271 Neighboring gene Sharpr-MPRA regulatory region 15086 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853156-38853678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853679-38854200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27277 Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 279 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:39038237-39039436 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:39084432-39085631 Neighboring gene lysine acetyltransferase 2B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cone-rod dystrophy 9
MedGen: C1423873 OMIM: 612775 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • KIAA0021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding PubMed 
enables SH3 domain binding PubMed 
enables collagen binding PubMed 
enables integrin binding  
enables integrin binding PubMed 
enables integrin binding PubMed 
enables integrin binding PubMed 
enables laminin binding PubMed 
enables metal ion binding  
enables metalloendopeptidase activity  
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process PubMed 
enables metallopeptidase activity PubMed 
enables protein binding PubMed 
enables protein kinase C binding PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in amyloid precursor protein catabolic process PubMed 
involved_in cell adhesion PubMed 
involved_in cell adhesion mediated by integrin PubMed 
involved_in cell adhesion mediated by integrin  
involved_in cell migration  
involved_in cell-cell adhesion mediated by integrin  
involved_in cell-cell adhesion mediated by integrin PubMed 
involved_in cell-matrix adhesion PubMed 
involved_in cellular response to lipopolysaccharide PubMed 
involved_in integrin-mediated signaling pathway PubMed 
involved_in keratinocyte differentiation PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis PubMed 
acts_upstream_of_or_within membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis PubMed 
acts_upstream_of_or_within membrane protein intracellular domain proteolysis PubMed 
involved_in monocyte activation PubMed 
acts_upstream_of positive regulation of MAP kinase activity PubMed 
involved_in positive regulation of cell adhesion mediated by integrin PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of keratinocyte migration PubMed 
involved_in positive regulation of macrophage fusion PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis PubMed 
involved_in positive regulation of protein secretion PubMed 
involved_in protein processing PubMed 
involved_in response to antineoplastic agent  
involved_in response to calcium ion PubMed 
involved_in response to glucocorticoid PubMed 
involved_in response to hydrogen peroxide PubMed 
involved_in response to laminar fluid shear stress  
involved_in response to manganese ion PubMed 
involved_in response to tumor necrosis factor PubMed 
involved_in transforming growth factor beta receptor signaling pathway  
involved_in transforming growth factor beta receptor signaling pathway PubMed 
involved_in transforming growth factor beta receptor signaling pathway PubMed 
Items 1 - 25 of 35
Component Evidence Code Pubs
located_in basolateral plasma membrane  
located_in cell surface PubMed 
located_in external side of plasma membrane PubMed 
located_in extracellular exosome PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space PubMed 
located_in focal adhesion PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 9
Names
ADAM metallopeptidase domain 9 (meltrin gamma)
cellular disintegrin-related protein
cone rod dystrophy 9
metalloprotease/disintegrin/cysteine-rich protein 9
myeloma cell metalloproteinase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016335.2 RefSeqGene

    Range
    5002..113290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003816.3NP_003807.1  disintegrin and metalloproteinase domain-containing protein 9 precursor

    See identical proteins and their annotated locations for NP_003807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein coding transcript.
    Source sequence(s)
    AC105091, AC108863
    Consensus CDS
    CCDS6112.1
    UniProtKB/Swiss-Prot
    B7ZLN7, Q10718, Q13443, Q8NFM6
    UniProtKB/TrEMBL
    A0A7I2V4B3
    Related
    ENSP00000419446.2, ENST00000487273.7
    Conserved Domains (5) summary
    smart00608
    Location:500636
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:212404
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:423497
    Disintegrin; Disintegrin
    pfam01421
    Location:212406
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:55162
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. NR_027638.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.
    Source sequence(s)
    AC105091, AC108863, AV708278, BC027996, BC126406, BC143923
    Related
    ENST00000481873.7
  2. NR_027639.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.
    Source sequence(s)
    AC105091, AC108863, AV708278, BC027996, BC143924
    Related
    ENST00000468065.5
  3. NR_027878.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105091, AC108863
    Related
    ENST00000379917.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38996973..39105261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422390.1XP_047278346.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A7I2V3C1
    Related
    ENSP00000503418.1, ENST00000678474.1
  2. XM_011544682.3XP_011542984.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A7I2V4B3
    Conserved Domains (5) summary
    smart00608
    Location:482618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:194386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:405479
    Disintegrin; Disintegrin
    pfam01421
    Location:194388
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:37144
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_007060759.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187577.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    7546..10944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    39274115..39382400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361438.1XP_054217413.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A7I2V3C1
  2. XM_054361437.1XP_054217412.1  disintegrin and metalloproteinase domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A7I2V4B3

RNA

  1. XR_008487888.1 RNA Sequence

External link. Please review our privacy policy.