TNFRSF6B TNF receptor superfamily member 6b [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNFRSF6Bprovided by HGNC
Official Full Name: TNF receptor superfamily member 6bprovided by HGNC
Primary source: HGNC:HGNC:11921
See related: Ensembl:ENSG00000243509 MIM:603361; AllianceGenome:HGNC:11921
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: M68; TR6; DCR3; M68E; DJ583P15.1.1
Summary: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Expression: Broad expression in appendix (RPKM 7.2), spleen (RPKM 3.2) and 20 other tissues See more
Orthologs: all
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Genomic context

Location:: 20q13.33

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (63696652..63698684)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65516958..65518990)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (62328005..62330037)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIF-1alpha regulates DcR3 to promote the development of endometriosis.
Title: HIF-1α regulates DcR3 to promote the development of endometriosis.
[miR-148b inhibits M2 polarization of LPS-stimulated macrophages by targeting DcR3].
Title: [miR-148b inhibits M2 polarization of LPS-stimulated macrophages by targeting DcR3].
Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation.
Title: Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation.
TNFSF/TNFRSF cytokine gene expression in sickle cell anemia: Up-regulated TNF-like cytokine 1A (TL1A) and its decoy receptor (DcR3) in peripheral blood mononuclear cells and plasma.
Title: TNFSF/TNFRSF cytokine gene expression in sickle cell anemia: Up-regulated TNF-like cytokine 1A (TL1A) and its decoy receptor (DcR3) in peripheral blood mononuclear cells and plasma.
Hepatitis B X protein upregulates decoy receptor 3 expression via the PI3K/NF-kappaB pathway.
Title: Hepatitis B X protein upregulates decoy receptor 3 expression via the PI3K/NF-κB pathway.
The expression of DcR3 might be involved in the differentiation and progression of lung adenocarcinoma.
Title: Decoy Receptor 3 Expression Is Associated With Wild-Type EGFR Status, Poor Differentiation of Tumor, and Unfavorable Patient Outcome.
The levels of plasma DcR3 in preeclamptic women were significantly lower than those of normal pregnant women, suggesting that a potential involvement of DcR3 in normal pregnancy and decreased levels of DcR3 may be related to preeclampsia.
Title: Low plasma levels of decoy receptor 3 (DcR3) in the third trimester of pregnancy with preeclampsia.
DcR3 was highly expressed in patients with acute-on-chronic liver failure and correlated with several clinical indices. Dynamic change of DcR3 might predict the prognosis of acute-on-chronic liver failure .
Title: Expression and Clinical Significance of Decoy Receptor 3 in Acute-on-Chronic Liver Failure.
significantly higher levels of TL1A and its decoy receptor DcR3 in RA patients than in controls; TL1A is significantly related to the disease activity and enhances IL-17 production
Title: Association of Tumor Necrosis Like factor 1 A (TL1A) and its Decoy Receptor (DcR3) with The Disease Activity and Autoantibody Production in Rheumatoid Arthritis Patients.
Aberrant expression of DcR3, which is upregulated by oestrogen 25, is an important pathogenic factor in inducing endometriosis.
Title: Decoy receptor 3 promotes cell adhesion and enhances endometriosis development.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of glioma and meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough RTEL1-TNFRSF6B

Readthrough gene: RTEL1-TNFRSF6B, Included gene: RTEL1

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6B

Names: decoy receptor for Fas ligand; tumor necrosis factor receptor superfamily, member 6b, decoy

NP_003814.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046961.1 RefSeqGene

Range

5002..7034

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003823.4 → NP_003814.1 tumor necrosis factor receptor superfamily member 6B precursor

See identical proteins and their annotated locations for NP_003814.1

Status: REVIEWED

Source sequence(s)

AW204999, BC034349, BM759033

Consensus CDS

CCDS13532.1

UniProtKB/Swiss-Prot

O95407

Related

ENSP00000359013.1, ENST00000369996.3

Conserved Domains (1) summary

cd10575
Location:34 → 196

TNFRSF6B; Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), also known as decoy receptor 3 (DcR3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

63696652..63698684

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

65516958..65518990

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_032945.2: Suppressed sequence

Description

NM_032945.2: This RefSeq was permanently suppressed because it represents a read-through transcript and it is now thought that this transcript does not encode a protein.