CCN5 cellular communication network factor 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCN5provided by HGNC
Official Full Name: cellular communication network factor 5provided by HGNC
Primary source: HGNC:HGNC:12770
See related: Ensembl:ENSG00000064205 MIM:603399; AllianceGenome:HGNC:12770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT58; WISP2; CTGF-L
Summary: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
Expression: Biased expression in ovary (RPKM 59.2), fat (RPKM 22.7) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (44714861..44727811)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (46450611..46463559)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (43343502..43356452)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion via Activating Wnt/beta-Catenin Signaling.
Title: SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion via Activating Wnt/β-Catenin Signaling.
WISP2 downregulation inhibits the osteogenic differentiation of BMSCs in congenital scoliosis by regulating Wnt/beta-catenin pathway.
Title: WISP2 downregulation inhibits the osteogenic differentiation of BMSCs in congenital scoliosis by regulating Wnt/β-catenin pathway.
ERalpha prevents tumorigenesis of both liver and breast cancer cells through CCN5.
Title: ERα prevents tumorigenesis of both liver and breast cancer cells through CCN5.
Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia.
Title: Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia.
LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis.
Title: LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis.
The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2.
Title: The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2.
WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.
Title: WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.
Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis.
Title: Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis.
Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment.
Title: Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment.
Protective effect of estrogen receptors (ERalpha/beta) against the intervertebral disc degeneration involves activating CCN5 via the promoter.
Title: Protective effect of estrogen receptors (ERα/β) against the intervertebral disc degeneration involves activating CCN5 via the promoter.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of WNT1 inducible signaling pathway protein 2 (WISP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCN family member 5

Names: WNT1 inducible signaling pathway protein 2; connective tissue growth factor-like protein; connective tissue growth factor-related protein 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001323369.2 → NP_001310298.1 CCN family member 5 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) retains an intron in its 5' UTR, and uses an alternate splice site and lacks an alternate exon in its 5' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AF083500, AL139352, BC058074

Consensus CDS

CCDS82619.1

UniProtKB/Swiss-Prot

O76076

Related

ENSP00000361956.4, ENST00000372865.4

Conserved Domains (1) summary

pfam00219
Location:42 → 78

IGFBP; Insulin-like growth factor binding protein
NM_001323370.2 → NP_001310299.1 CCN family member 5 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AL139352, BI823598, BU623413

Consensus CDS

CCDS13336.1

UniProtKB/Swiss-Prot

B2R9N4, E1P612, O76076, Q6PEG3

Related

ENSP00000361959.2, ENST00000372868.6

Conserved Domains (2) summary

pfam00219
Location:44 → 78

IGFBP; Insulin-like growth factor binding protein

cl17735
Location:100 → 160

VWC; von Willebrand factor type C domain
NM_003881.4 → NP_003872.1 CCN family member 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_003872.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) retains an intron in its 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

BC017782, BU623413

Consensus CDS

CCDS13336.1

UniProtKB/Swiss-Prot

B2R9N4, E1P612, O76076, Q6PEG3

Related

ENSP00000190983.4, ENST00000190983.5

Conserved Domains (2) summary

pfam00219
Location:44 → 78

IGFBP; Insulin-like growth factor binding protein

cl17735
Location:100 → 160

VWC; von Willebrand factor type C domain