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devS two component sensor histidine kinase DevS [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888829, updated on 6-Oct-2023

Summary

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Gene symbol
devS
Gene description
two component sensor histidine kinase DevS
Locus tag
Rv3132c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
dosS
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Genomic context

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Sequence:
NC_000962.3 (3497529..3499265, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene diacyglycerol O-acyltransferase Neighboring gene NAD(P)H nitroreductase Neighboring gene two component transcriptional regulator DevR Neighboring gene universal stress protein Neighboring gene PPE family protein PPE50

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of the CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis. Madrona Y, et al. Arch Biochem Biophys, 2016 Dec 15. PMID 27729224, Free PMC Article
  2. A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem. Sardiwal S, et al. J Mol Biol, 2005 Nov 11. PMID 16213520
  3. Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS. Basudhar D, et al. J Biol Chem, 2016 Jul 29. PMID 27235395, Free PMC Article
  4. Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif. Cho HY, et al. J Biol Chem, 2013 May 3. PMID 23486471, Free PMC Article
  5. DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions. Gautam US, et al. Am J Respir Cell Mol Biol, 2015 Jun. PMID 25322074, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oxygen triggers signal transduction in the DevS heme-oxygen sensor of Mycobacterium tuberculosis by modulating its quaternary structure.
    Title: Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure.
  2. DevS is a bifunctional sensor and possesses a robust phosphatase activity toward DevR.
    Title: DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.
  3. analysis of CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis
    Title: Crystal structures of the CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis.
  4. Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS.
    Title: Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS.
  5. DosS, but not DosR and DosT, is required by Mycobacterium tuberculosis to survive in C3HeB/FeJ mice.
    Title: DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions.
  6. Unlike other histidine kinases containing an ATP lid, which protects bound ATP, DosS is unable to accept ATP until the ABD is properly positioned relative to the histidine; this may prevent unexpected ATP reactions.
    Title: Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif.
  7. Despite its similarity to DosT, DosS displays ligand-specific different primary dynamics during the initial phases of intraprotein signaling, in which the distal tyrosine, present in both proteins, plays an important role.
    Title: Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis.
  8. Transcription of the DosR regulon is controlled through a two-component regulatory system comprising the transcription factor DosR and two possible cognate histidine sensor kinases, DosS and DosT.
    Title: Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants.
  9. Both sensors DosS and DosT are necessary for wild-type levels of DosR regulon induction, and concomitantly, full induction of the regulon is required for wild-type anaerobic survival.
    Title: Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy.
  10. The autoxidation properties of DevS clearly indicate that DevS functions as a gas sensor in vivo; its stability to autoxidation is enhanced by interdomain interactions.
    Title: DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy.
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Homology

General protein information

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Preferred Names
two component sensor histidine kinase DevS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3497529..3499265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217648.1 two component sensor histidine kinase DevS [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217648.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WBL6
    Conserved Domains (3) summary
    smart00065
    Location:63 → 208
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    COG4585
    Location:384 → 576
    COG4585; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam13185
    Location:230 → 358
    GAF_2; GAF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGK3.1

Gene LinkOut

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Molecular Biology Databases