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devR two component transcriptional regulator DevR [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888842, updated on 6-Oct-2023

Summary

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Gene symbol
devR
Gene description
two component transcriptional regulator DevR
Locus tag
Rv3133c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
dosR
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Genomic context

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Sequence:
NC_000962.3 (3499262..3499915, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene diacyglycerol O-acyltransferase Neighboring gene NAD(P)H nitroreductase Neighboring gene two component sensor histidine kinase DevS Neighboring gene universal stress protein Neighboring gene PPE family protein PPE50

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cognate sensor kinase-independent activation of Mycobacterium tuberculosis response regulator DevR (DosR) by acetyl phosphate: implications in anti-mycobacterial drug design. Sharma S, et al. Mol Microbiol, 2019 May. PMID 30589958
  2. Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. Wisedchaisri G, et al. J Mol Biol, 2005 Dec 2. PMID 16246368
  3. Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. Wisedchaisri G, et al. J Mol Biol, 2008 Apr 18. PMID 18353359, Free PMC Article
  4. Interaction of DevR with multiple binding sites synergistically activates divergent transcription of narK2-Rv1738 genes in Mycobacterium tuberculosis. Chauhan S, et al. J Bacteriol, 2008 Aug. PMID 18502855, Free PMC Article
  5. Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Converse PJ, et al. Infect Immun, 2009 Mar. PMID 19103767, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli.
    Title: Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli.
  2. Acetate induces activation of the DevR regulon in a sensor kinase-independent manner.
    Title: Cognate sensor kinase-independent activation of Mycobacterium tuberculosis response regulator DevR (DosR) by acetyl phosphate: implications in anti-mycobacterial drug design.
  3. DevR forms a heterodimer with PhoPRv; puts forward a new possible mechanism for coordinated expression of the dormancy regulon
    Title: Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis.
  4. Acetylated K182 plays an important role in the DNA-binding ability of DosR and that acetylation of K182 completely abolished the affinity of DosR for DNA.
    Title: Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia.
  5. Hypoxia induces the deacetylation of DosR, which in turn increases its DNA-binding ability to promote the transcription of target genes.
    Title: Lysine acetylation of DosR regulates the hypoxia response of Mycobacterium tuberculosis.
  6. Persistent expression of HspX and the accumulation of triacylglycerols reveal a previously underappreciated role of DevR during adaptation to extended hypoxia in mycobacterium tuberculosis.
    Title: Sustained expression of DevR/DosR during long-term hypoxic culture of Mycobacterium tuberculosis.
  7. In sputum samples from patients with tuberculosis the DosR regulon was significantly less expressed in M. africanum L6 compared to M. tuberculosis L4.
    Title: Significant under expression of the DosR regulon in M. tuberculosis complex lineage 6 in sputum.
  8. Transcriptional profiling and DNA-binding assays suggested that Cmr directly represses dosR expression.
    Title: Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.
  9. DevS is a bifunctional sensor and possesses a robust phosphatase activity toward DevR.
    Title: DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.
  10. Observed significant changes in the proportions of CD45RO(+)CD27(+) T cells to specific DosR and Rpf, which may indicate a persistent immune response to Mtb antigens in long term tuberculosis infection.
    Title: Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients.
Submit: New GeneRIF Correction See all GeneRIFs (34)

General gene information

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Homology

General protein information

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Preferred Names
two component transcriptional regulator DevR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3499262..3499915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217649.1 two component transcriptional regulator DevR [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217649.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WC47
    Conserved Domains (1) summary
    COG2197
    Location:3 → 208
    CitB; DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMF9.1

Gene LinkOut

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Research Materials