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Pdk4 pyruvate dehydrogenase kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89813, updated on 2-Nov-2024

Summary

Official Symbol
Pdk4provided by RGD
Official Full Name
pyruvate dehydrogenase kinase 4provided by RGD
Primary source
RGD:69061
See related
EnsemblRapid:ENSRNOG00000009565 AllianceGenome:RGD:69061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in protein phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 473.1), Heart (RPKM 258.8) and 6 other tissues See more
Orthologs
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Genomic context

See Pdk4 in Genome Data Viewer
Location:
4q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (34558327..34568329, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (33591796..33601798, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (30546772..30556774, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552448 Neighboring gene villin 1, pseudogene 1 Neighboring gene ribosomal protein S29, pseudogene 20 Neighboring gene dynein cytoplasmic 1 intermediate chain 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular ketone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
pyruvate dehydrogenase kinase, isozyme 4
Names
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
pyruvate dehydrogenase kinase, isoenzyme 4
pyruvate dehydrogenate kinase 4
NP_446003.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053551.2NP_446003.2  pyruvate dehydrogenase kinase, isozyme 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    O54937
    UniProtKB/TrEMBL
    A6IDT8, G3V778
    Related
    ENSRNOP00000012759.1, ENSRNOT00000012760.6
    Conserved Domains (2) summary
    cd16929
    Location:199365
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:34195
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    34558327..34568329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)