Cxadr CXADR, Ig-like cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxadrprovided by RGD
Official Full Name: CXADR, Ig-like cell adhesion moleculeprovided by RGD
Primary source: RGD:619794
See related: Ensembl:ENSRNOG00000001557 AllianceGenome:RGD:619794
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Car1
Summary: Predicted to enable several functions, including PDZ domain binding activity; beta-catenin binding activity; and connexin binding activity. Predicted to be involved in several processes, including AV node cell-bundle of His cell adhesion involved in cell communication; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and neutrophil chemotaxis. Predicted to act upstream of or within negative regulation of cardiac muscle cell proliferation. Located in bicellular tight junction and neuron projection. Orthologous to human CXADR (CXADR Ig-like cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 191.2), Heart (RPKM 168.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (30469778..30516990)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (16982864..17030078)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (16826269..16873564)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively
Title: miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
CAR-positive cells are pituitary stem/progenitor cells and compose putative stem/progenitor cell niches in the MCL and parenchyma.
Title: Coxsackievirus and adenovirus receptor-positive cells compose the putative stem/progenitor cell niches in the marginal cell layer and parenchyma of the rat anterior pituitary.
CAR is not only a structural protein: it is involved in conferring the phosphorylation status of other adhesion proteins at the blood-testis barrier.
Title: Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.
it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis
Title: CAR-associated vesicular transport of an adenovirus in motor neuron axons.
expression of coxsackievirus and adenovirus receptor (CAR), the major receptor of coxsackievirus B5 (CVB5), was down-regulated in mature neurons; data support that level of CAR in neurons is a determinant in age-dependency of CBV5 virulence in CNS
Title: Primary neurons become less susceptible to coxsackievirus B5 following maturation: the correlation with the decreased level of CAR expression on cell surface.
coxsackievirus and adenovirus receptor (CAR) was expressed abundantly on the whole surface of cardiomyocytes in immature rat hearts
Title: Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat.
CAR functions as an adhesion molecule in maintaining the inter-Sertoli cell junctions at the basal compartment of the seminiferous epithelium. In addition, CAR may confer adhesion between Sertoli and germ cells at the Sertoli-germ cell interface.
Title: Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface.
is an integral membrane component of tight junction in podocytes and that CAR expression in podocytes is regulated at the transcriptional level and in the redistribution of protein
Title: Coxsackievirus and adenovirus receptor, a tight junction membrane protein, is expressed in glomerular podocytes in the kidney.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137702 (e-PCR)
- UniSTS:219789

AU049654 (e-PCR)
- UniSTS:146100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISS Inferred from Sequence or Structural Similarity more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables connexin binding	ISO Inferred from Sequence Orthology more info
enables connexin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AV node cell to bundle of His cell communication	ISO Inferred from Sequence Orthology more info
involved_in AV node cell to bundle of His cell communication	ISS Inferred from Sequence or Structural Similarity more info
involved_in AV node cell-bundle of His cell adhesion involved in cell communication	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamma-delta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in gamma-delta T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell migration	ISO Inferred from Sequence Orthology more info
involved_in germ cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in homotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coxsackievirus and adenovirus receptor homolog

Names: CAR; coxsackie virus and adenovirus receptor; rCAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399207.1 → NP_001386136.1 coxsackievirus and adenovirus receptor homolog isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q5M817, Q9R066, Q9R067

UniProtKB/TrEMBL

A6JL35

Conserved Domains (3) summary

cd00096
Location:149 → 153

Ig; Ig strand A' [structural motif]

cd20960
Location:20 → 136

IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins

cl11960
Location:147 → 229

Ig; Immunoglobulin domain
NM_053570.2 → NP_446022.1 coxsackievirus and adenovirus receptor homolog isoform 2 precursor

See identical proteins and their annotated locations for NP_446022.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JL34

Related

ENSRNOP00000041873.3, ENSRNOT00000050701.4

Conserved Domains (3) summary

smart00410
Location:27 → 137

IG_like; Immunoglobulin like

pfam07686
Location:24 → 138

V-set; Immunoglobulin V-set domain

cl11960
Location:154 → 222

Ig; Immunoglobulin domain