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PGLYRP1 peptidoglycan recognition protein 1 [ Homo sapiens (human) ]

Gene ID: 8993, updated on 2-Nov-2024

Summary

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Official Symbol
PGLYRP1provided by HGNC
Official Full Name
peptidoglycan recognition protein 1provided by HGNC
Primary source
HGNC:HGNC:8904
See related
Ensembl:ENSG00000008438 MIM:604963; AllianceGenome:HGNC:8904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L
Summary
Enables several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward bone marrow (RPKM 135.5) See more
Orthologs
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Genomic context

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See PGLYRP1 in Genome Data Viewer
Location:
19q13.32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46019153..46023053, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48846608..48850508, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46522411..46526311, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14833 Neighboring gene Sharpr-MPRA regulatory region 4903 Neighboring gene coiled-coil domain containing 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46506355-46506854 Neighboring gene Sharpr-MPRA regulatory region 13926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46524919-46525804 Neighboring gene microRNA 769 Neighboring gene uncharacterized LOC105372421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity. Cho JH, et al. Blood, 2005 Oct 1. PMID 15956276, Free PMC Article
  2. Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells. Sharapova TN, et al. J Innate Immun, 2017. PMID 28977785
  3. The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria. Yashin DV, et al. Biochimie, 2016 Apr. PMID 26796882
  4. Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. Sharapova TN, et al. J Immunol Res, 2018. PMID 29850628, Free PMC Article
  5. Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Luo Q, et al. Mol Med Rep, 2019 Jan. PMID 30431075

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
    Title: The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
  2. Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1beta levels during menopause.
    Title: Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1β levels during menopause.
  3. Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study.
    Title: Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study.
  4. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.
    Title: N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.
  5. TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the ""enemy"" a friend.
    Title: TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the "enemy" a friend.
  6. Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure.
    Title: Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure.
  7. Cytokines TNFalpha, IFNgamma and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.
    Title: Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.
  8. Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells.
    Title: Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells.
  9. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
    Title: A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
  10. Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
    Title: Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126894, MGC126896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan immune receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan immune receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biological process involved in interaction with host IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in killing of cells of another organism IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of natural killer cell differentiation involved in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle lumen TAS
Traceable Author Statement
more info
  
located_in specific granule lumen TAS
Traceable Author Statement
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
peptidoglycan recognition protein 1
Names
TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005091.3 → NP_005082.1  peptidoglycan recognition protein 1 precursor

    See identical proteins and their annotated locations for NP_005082.1

    Status: VALIDATED

    Source sequence(s)
    AF242517, DN998360
    Consensus CDS
    CCDS12680.1
    UniProtKB/Swiss-Prot
    O75594, Q4VB36
    Related
    ENSP00000008938.3, ENST00000008938.5
    Conserved Domains (1) summary
    smart00701
    Location:31 → 173
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46019153..46023053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48846608..48850508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75594.1 GenPept UniProtKB/Swiss-Prot:O75594

Gene LinkOut

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