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CEACAM21 CEA cell adhesion molecule 21 [ Homo sapiens (human) ]

Gene ID: 90273, updated on 2-Nov-2024

Summary

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Official Symbol
CEACAM21provided by HGNC
Official Full Name
CEA cell adhesion molecule 21provided by HGNC
Primary source
HGNC:HGNC:28834
See related
Ensembl:ENSG00000007129 MIM:618191; AllianceGenome:HGNC:28834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEACAM3; R29124_1
Summary
Predicted to be involved in T cell activation. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lymph node (RPKM 2.0), bone marrow (RPKM 1.9) and 15 other tissues See more
Orthologs
all
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Genomic context

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See CEACAM21 in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41549518..41586844)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44371274..44408596)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42055886..42093197)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1480 Neighboring gene Sharpr-MPRA regulatory region 9744 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene Sharpr-MPRA regulatory region 9748 Neighboring gene uncharacterized LOC105372404 Neighboring gene CEA cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The old CEACAMs find their new role in tumor immunotherapy. Han ZW, et al. Invest New Drugs, 2020 Dec. PMID 32488569
  2. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Amin Al Olama A, et al. Hum Mol Genet, 2013 Jan 15. PMID 23065704, Free PMC Article
  3. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. Alkelai A, et al. Int J Neuropsychopharmacol, 2012 May. PMID 21682944
  4. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study revealed CEACAM21 as novel schizophrenia candidate genes in the Jewish population
    Title: DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
EBI GWAS Catalog
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13540, MGC119874, AC006129.2

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 21
Names
carcinoembryonic antigen related cell adhesion molecule 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098506.4 → NP_001091976.3  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001091976.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC243960, AY358084, BC012001, BC106727
    Consensus CDS
    CCDS46086.1
    UniProtKB/Swiss-Prot
    B7WNQ6, O75296, Q3KPI0, Q6UY47, Q96ER7
    UniProtKB/TrEMBL
    A0A0G2JSC8
    Related
    ENSP00000385739.2, ENST00000401445.4
    Conserved Domains (2) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:142 → 232
    Ig; Immunoglobulin domain

  2. NM_001288773.3 → NP_001275702.2  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 3

    See identical proteins and their annotated locations for NP_001275702.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, compared to variant 1, and initiates translation at an alternate start codon. The resulting isoform (3) is shorter and has a different N-terminus, compared to isoform 1.
    Source sequence(s)
    AK023602, AY358084, BC012001, BI913326
    Consensus CDS
    CCDS74373.1
    UniProtKB/TrEMBL
    A0A0B4J1W4
    Related
    ENSP00000384380.1, ENST00000407170.6
    Conserved Domains (2) summary
    cd00096
    Location:18 → 22
    Ig; Ig strand A [structural motif]
    cl11960
    Location:18 → 104
    Ig; Immunoglobulin domain

  3. NM_001290113.2 → NP_001277042.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 4

    See identical proteins and their annotated locations for NP_001277042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a different N-terminus, compared to isoform 1.
    Source sequence(s)
    AC243960, AY358084, BC012001
    UniProtKB/Swiss-Prot
    Q3KPI0
    Conserved Domains (2) summary
    smart00410
    Location:24 → 104
    IG_like; Immunoglobulin like
    cl11960
    Location:14 → 104
    Ig; Immunoglobulin domain

  4. NM_033543.6 → NP_291021.4  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 2 precursor

    See identical proteins and their annotated locations for NP_291021.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC243960, AY358084, BC012001
    Consensus CDS
    CCDS46087.1
    UniProtKB/Swiss-Prot
    Q3KPI0
    Related
    ENSP00000187608.9, ENST00000187608.13
    Conserved Domains (3) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:152 → 232
    IG_like; Immunoglobulin like
    cl11960
    Location:142 → 232
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41549518..41586844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439609.1 → XP_047295565.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

  2. XM_017027430.2 → XP_016882919.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  3. XM_017027431.2 → XP_016882920.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  4. XM_017027432.3 → XP_016882921.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  5. XM_047439608.1 → XP_047295564.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  6. XM_005278397.5 → XP_005278454.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

    See identical proteins and their annotated locations for XP_005278454.1

    UniProtKB/Swiss-Prot
    Q3KPI0
    Conserved Domains (3) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:152 → 232
    IG_like; Immunoglobulin like
    cl11960
    Location:142 → 232
    Ig; Immunoglobulin domain

  7. XM_047439610.1 → XP_047295566.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JS40
    Related
    ENSP00000390697.1, ENST00000457737.5

  8. XM_047439611.1 → XP_047295567.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1W4

  9. XM_047439612.1 → XP_047295568.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    95157..132483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329431.1 → XP_054185406.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  2. XM_054329430.1 → XP_054185405.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  3. XM_054329433.1 → XP_054185408.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  4. XM_054329432.1 → XP_054185407.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  5. XM_054329434.1 → XP_054185409.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

  6. XM_054329438.1 → XP_054185413.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

  7. XM_054329437.1 → XP_054185412.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1W4

  8. XM_054329435.1 → XP_054185410.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

  9. XM_054329436.1 → XP_054185411.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JS40

RNA

  1. XR_008485641.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44371274..44408596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322511.1 → XP_054178486.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

  2. XM_054322506.1 → XP_054178481.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  3. XM_054322507.1 → XP_054178482.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

  4. XM_054322508.1 → XP_054178483.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  5. XM_054322509.1 → XP_054178484.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

  6. XM_054322510.1 → XP_054178485.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

  7. XM_054322512.1 → XP_054178487.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JS40

  8. XM_054322513.1 → XP_054178488.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1W4

  9. XM_054322514.1 → XP_054178489.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

RNA

  1. XR_008485217.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KPI0.3 GenPept UniProtKB/Swiss-Prot:Q3KPI0

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