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PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

Gene ID: 9055, updated on 5-Mar-2024

Summary

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Official Symbol
PRC1provided by HGNC
Official Full Name
protein regulator of cytokinesis 1provided by HGNC
Primary source
HGNC:HGNC:9341
See related
Ensembl:ENSG00000198901 MIM:603484; AllianceGenome:HGNC:9341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASE1; MAP65
Summary
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90966040..90994535, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88725621..88754118, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509270..91537765, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91496471-91496971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:91497796-91498350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6834 Neighboring gene RCCD1 and UNC45A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6836 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:91526592-91527791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:91537071-91537938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:91537939-91538805 Neighboring gene uncharacterized LOC124903556 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:91547812-91547974 Neighboring gene VPS33B late endosome and lysosome associated Neighboring gene uncharacterized LOC105370970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib. Zhu P, et al. Eur Rev Med Pharmacol Sci, 2022 Dec. PMID 36524512
  2. Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus. Hanselmann S, et al. Cell Cycle, 2023 Feb. PMID 36135961, Free PMC Article
  3. Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma. Zhang C, et al. J Immunol Res, 2022. PMID 35983074, Free PMC Article
  4. Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction. Eeftens JM, et al. Nat Commun, 2021 Oct 7. PMID 34620850, Free PMC Article
  5. Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption. Alfieri A, et al. Curr Biol, 2021 Jun 21. PMID 33848456

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein regulator of cytokinesis 1: a potential oncogenic driver.
    Title: Protein regulator of cytokinesis 1: a potential oncogenic driver.
  2. Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
    Title: Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
  3. Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
    Title: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
  4. CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
    Title: CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
  5. Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
    Title: Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
  6. PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
    Title: PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
  7. Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
    Title: Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
  8. Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
    Title: Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
  9. Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
    Title: Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
  10. TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis.
    Title: TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1671, MGC3669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle elongation TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule TAS
Traceable Author Statement
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein regulator of cytokinesis 1
Names
anaphase spindle elongation 1 homolog
protein regulating cytokinesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050647.2 RefSeqGene

    Range
    5000..33495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267580.2 → NP_001254509.2  protein regulator of cytokinesis 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS45353.2
    Related
    ENSP00000409549.2, ENST00000442656.6
    Conserved Domains (1) summary
    pfam03999
    Location:22 → 508
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  2. NM_003981.4 → NP_003972.2  protein regulator of cytokinesis 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS32334.1
    UniProtKB/Swiss-Prot
    A6NC44, B4DLR1, H9KV59, O43663, Q9BSB6
    Related
    ENSP00000377793.3, ENST00000394249.8
    Conserved Domains (1) summary
    pfam03999
    Location:37 → 615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

  3. NM_199413.3 → NP_955445.2  protein regulator of cytokinesis 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC068831
    Consensus CDS
    CCDS45352.1
    Related
    ENSP00000354679.5, ENST00000361188.9
    Conserved Domains (1) summary
    COG1196
    Location:96 → 414
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90966040..90994535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022714.3 → XP_016878203.1  protein regulator of cytokinesis 1 isoform X7

  2. XM_047433314.1 → XP_047289270.1  protein regulator of cytokinesis 1 isoform X29

  3. XM_047433310.1 → XP_047289266.1  protein regulator of cytokinesis 1 isoform X26

  4. XM_011522192.3 → XP_011520494.1  protein regulator of cytokinesis 1 isoform X20

    Conserved Domains (4) summary
    pfam03999
    Location:37 → 494
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:306 → 444
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    pfam13094
    Location:35 → 180
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cl00711
    Location:141 → 304
    Glyco_hydro_77; 4-alpha-glucanotransferase

  5. XM_047433313.1 → XP_047289269.1  protein regulator of cytokinesis 1 isoform X28

  6. XM_047433311.1 → XP_047289267.1  protein regulator of cytokinesis 1 isoform X27

  7. XM_047433305.1 → XP_047289261.1  protein regulator of cytokinesis 1 isoform X21

  8. XM_047433306.1 → XP_047289262.1  protein regulator of cytokinesis 1 isoform X22

  9. XM_047433300.1 → XP_047289256.1  protein regulator of cytokinesis 1 isoform X16

  10. XM_047433301.1 → XP_047289257.1  protein regulator of cytokinesis 1 isoform X17

  11. XM_047433309.1 → XP_047289265.1  protein regulator of cytokinesis 1 isoform X25

  12. XM_047433307.1 → XP_047289263.1  protein regulator of cytokinesis 1 isoform X23

  13. XM_047433298.1 → XP_047289254.1  protein regulator of cytokinesis 1 isoform X13

  14. XM_017022716.3 → XP_016878205.1  protein regulator of cytokinesis 1 isoform X14

  15. XM_011522190.4 → XP_011520492.1  protein regulator of cytokinesis 1 isoform X9

    Conserved Domains (4) summary
    pfam03999
    Location:37 → 544
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:356 → 494
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    pfam13094
    Location:35 → 194
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    cl00711
    Location:203 → 354
    Glyco_hydro_77; 4-alpha-glucanotransferase

  16. XM_047433297.1 → XP_047289253.1  protein regulator of cytokinesis 1 isoform X11

  17. XM_047433304.1 → XP_047289260.1  protein regulator of cytokinesis 1 isoform X19

  18. XM_047433299.1 → XP_047289255.1  protein regulator of cytokinesis 1 isoform X15

  19. XM_047433295.1 → XP_047289251.1  protein regulator of cytokinesis 1 isoform X5

  20. XM_017022713.3 → XP_016878202.1  protein regulator of cytokinesis 1 isoform X6

  21. XM_011522189.3 → XP_011520491.1  protein regulator of cytokinesis 1 isoform X3

    Conserved Domains (2) summary
    pfam03999
    Location:37 → 564
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  22. XM_017022712.3 → XP_016878201.1  protein regulator of cytokinesis 1 isoform X4

  23. XM_006720760.3 → XP_006720823.1  protein regulator of cytokinesis 1 isoform X12

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 562
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 562
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  24. XM_005254987.4 → XP_005255044.1  protein regulator of cytokinesis 1 isoform X8

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  25. XM_006720759.3 → XP_006720822.1  protein regulator of cytokinesis 1 isoform X10

    See identical proteins and their annotated locations for XP_006720822.1

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 560
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  26. XM_011522188.4 → XP_011520490.1  protein regulator of cytokinesis 1 isoform X2

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 583
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  27. XM_011522187.3 → XP_011520489.1  protein regulator of cytokinesis 1 isoform X1

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 551
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

  28. XM_047433308.1 → XP_047289264.1  protein regulator of cytokinesis 1 isoform X24

  29. XM_047433303.1 → XP_047289259.1  protein regulator of cytokinesis 1 isoform X18

  30. XM_011522191.4 → XP_011520493.1  protein regulator of cytokinesis 1 isoform X10

    See identical proteins and their annotated locations for XP_011520493.1

    Conserved Domains (3) summary
    pfam03999
    Location:37 → 549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam08418
    Location:413 → 560
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    cl00711
    Location:260 → 411
    Glyco_hydro_77; 4-alpha-glucanotransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88725621..88754118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379147.1 → XP_054235122.1  protein regulator of cytokinesis 1 isoform X7

  2. XM_054379170.1 → XP_054235145.1  protein regulator of cytokinesis 1 isoform X29

  3. XM_054379167.1 → XP_054235142.1  protein regulator of cytokinesis 1 isoform X26

  4. XM_054379161.1 → XP_054235136.1  protein regulator of cytokinesis 1 isoform X20

  5. XM_054379169.1 → XP_054235144.1  protein regulator of cytokinesis 1 isoform X28

  6. XM_054379168.1 → XP_054235143.1  protein regulator of cytokinesis 1 isoform X27

  7. XM_054379162.1 → XP_054235137.1  protein regulator of cytokinesis 1 isoform X21

  8. XM_054379163.1 → XP_054235138.1  protein regulator of cytokinesis 1 isoform X22

  9. XM_054379157.1 → XP_054235132.1  protein regulator of cytokinesis 1 isoform X16

  10. XM_054379158.1 → XP_054235133.1  protein regulator of cytokinesis 1 isoform X17

  11. XM_054379166.1 → XP_054235141.1  protein regulator of cytokinesis 1 isoform X25

  12. XM_054379164.1 → XP_054235139.1  protein regulator of cytokinesis 1 isoform X23

  13. XM_054379154.1 → XP_054235129.1  protein regulator of cytokinesis 1 isoform X13

  14. XM_054379155.1 → XP_054235130.1  protein regulator of cytokinesis 1 isoform X14

  15. XM_054379149.1 → XP_054235124.1  protein regulator of cytokinesis 1 isoform X9

  16. XM_054379151.1 → XP_054235126.1  protein regulator of cytokinesis 1 isoform X11

  17. XM_054379160.1 → XP_054235135.1  protein regulator of cytokinesis 1 isoform X19

  18. XM_054379156.1 → XP_054235131.1  protein regulator of cytokinesis 1 isoform X15

  19. XM_054379145.1 → XP_054235120.1  protein regulator of cytokinesis 1 isoform X5

  20. XM_054379146.1 → XP_054235121.1  protein regulator of cytokinesis 1 isoform X6

  21. XM_054379143.1 → XP_054235118.1  protein regulator of cytokinesis 1 isoform X3

  22. XM_054379144.1 → XP_054235119.1  protein regulator of cytokinesis 1 isoform X4

  23. XM_054379153.1 → XP_054235128.1  protein regulator of cytokinesis 1 isoform X12

  24. XM_054379148.1 → XP_054235123.1  protein regulator of cytokinesis 1 isoform X8

  25. XM_054379152.1 → XP_054235127.1  protein regulator of cytokinesis 1 isoform X10

  26. XM_054379142.1 → XP_054235117.1  protein regulator of cytokinesis 1 isoform X2

  27. XM_054379141.1 → XP_054235116.1  protein regulator of cytokinesis 1 isoform X1

  28. XM_054379165.1 → XP_054235140.1  protein regulator of cytokinesis 1 isoform X24

  29. XM_054379159.1 → XP_054235134.1  protein regulator of cytokinesis 1 isoform X18

  30. XM_054379150.1 → XP_054235125.1  protein regulator of cytokinesis 1 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199414.1: Suppressed sequence

    Description
    NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43663.2 GenPept UniProtKB/Swiss-Prot:O43663

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