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DPP9 dipeptidyl peptidase 9 [ Homo sapiens (human) ]

Gene ID: 91039, updated on 2-Nov-2024

Summary

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Official Symbol
DPP9provided by HGNC
Official Full Name
dipeptidyl peptidase 9provided by HGNC
Primary source
HGNC:HGNC:18648
See related
Ensembl:ENSG00000142002 MIM:608258; AllianceGenome:HGNC:18648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP9; DPLP9; DPRP2; HATIS; DPP IX; DPRP-2; IMD111
Summary
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Ubiquitous expression in spleen (RPKM 7.8), appendix (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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See DPP9 in Genome Data Viewer
Location:
19p13.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4675227..4723842, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4659400..4708159, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4675239..4723854, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4639529-4640528 Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4660681-4661180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4661482-4662252 Neighboring gene myeloid derived growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4675983-4676943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4679601-4680102 Neighboring gene DPP9 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4694063-4695262 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:4703720-4704919 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:4713085-4714284 Neighboring gene uncharacterized LOC105372250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9904 Neighboring gene tRNA-Gly (anticodon TCC) 1-1 Neighboring gene tRNA-Val (anticodon CAC) 3-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Contribution of upregulated dipeptidyl peptidase 9 (DPP9) in promoting tumoregenicity, metastasis and the prediction of poor prognosis in non-small cell lung cancer (NSCLC). Tang Z, et al. Int J Cancer, 2017 Apr 1. PMID 27943262, Free PMC Article
  2. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. Olsen C, et al. Gene, 2002 Oct 16. PMID 12459266
  3. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Ajami K, et al. Biochim Biophys Acta, 2004 Jul 13. PMID 15245913
  4. Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV. Bjelke JR, et al. Biochem J, 2006 Jun 1. PMID 16475979, Free PMC Article
  5. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. Qiu XS, et al. Postgrad Med J, 2008 Sep. PMID 18940951

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells.
    Title: DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells.
  2. Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
    Title: Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.
  3. DPP8/9 inhibition attenuates the TGF-beta1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.
    Title: DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.
  4. DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
    Title: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
  5. Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9.
    Title: Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9.
  6. Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain.
    Title: Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain.
  7. CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender.
    Title: CCR2 and DPP9 expression in the peripheral blood of COVID-19 patients: Influences of the disease severity and gender.
  8. Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.
    Title: Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.
  9. DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
    Title: DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
  10. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
    Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hatipoglu immunodeficiency syndrome
MedGen: C5830439 OMIM: 620331 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16073, DKFZp762F117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidyl-peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_negative_effect pyroptotic inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 9
Names
dipeptidyl peptidase IV-related protein-2
dipeptidyl peptidase IX
dipeptidyl peptidase-like protein 9
NP_001352916.1
NP_001371540.1
NP_001371541.1
NP_001371542.1
NP_001371543.1
NP_001371544.1
NP_001371545.1
NP_001371546.1
NP_001371547.1
NP_001371548.1
NP_001371549.1
NP_001371550.1
NP_001371551.1
NP_001371552.1
NP_001371553.1
NP_001371554.1
NP_001371555.1
NP_001371556.1
NP_001371557.1
NP_001371558.1
NP_001371559.1
NP_001371560.1
NP_001371561.1
NP_001371562.1
NP_001371563.1
NP_001371564.1
NP_001371565.1
NP_001371566.1
NP_001371567.1
NP_631898.3
XP_011526707.1
XP_047295608.1
XP_047295609.1
XP_047295610.1
XP_054178532.1
XP_054178533.1
XP_054178534.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365987.2 → NP_001352916.1  dipeptidyl peptidase 9 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 9, encodes isoform 2.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92492.1
    UniProtKB/TrEMBL
    M0R2A8
    Related
    ENSP00000472430.1, ENST00000597849.5
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 495
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. NM_001384611.1 → NP_001371540.1  dipeptidyl peptidase 9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  3. NM_001384612.1 → NP_001371541.1  dipeptidyl peptidase 9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000471629.2, ENST00000601130.6
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  4. NM_001384613.1 → NP_001371542.1  dipeptidyl peptidase 9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000472549.2, ENST00000600621.6
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  5. NM_001384614.1 → NP_001371543.1  dipeptidyl peptidase 9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  6. NM_001384615.1 → NP_001371544.1  dipeptidyl peptidase 9 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  7. NM_001384616.1 → NP_001371545.1  dipeptidyl peptidase 9 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92492.1
    UniProtKB/TrEMBL
    M0R2A8
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 495
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  8. NM_001384617.1 → NP_001371546.1  dipeptidyl peptidase 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:689 → 890
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  9. NM_001384618.1 → NP_001371547.1  dipeptidyl peptidase 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:682 → 883
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  10. NM_001384619.1 → NP_001371548.1  dipeptidyl peptidase 9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:680 → 881
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 588
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  11. NM_001384620.1 → NP_001371549.1  dipeptidyl peptidase 9 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform 6.
    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:678 → 879
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 586
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  12. NM_001384621.1 → NP_001371550.1  dipeptidyl peptidase 9 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform 6.
    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:678 → 879
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 586
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  13. NM_001384622.1 → NP_001371551.1  dipeptidyl peptidase 9 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000472224.1, ENST00000594671.5
    Conserved Domains (2) summary
    COG1506
    Location:533 → 864
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  14. NM_001384623.1 → NP_001371552.1  dipeptidyl peptidase 9 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 17-20, encodes isoform 7.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92491.1
    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:662 → 863
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:146 → 570
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  15. NM_001384624.1 → NP_001371553.1  dipeptidyl peptidase 9 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 16 and 18-20, encodes isoform 7.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92491.1
    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:662 → 863
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:146 → 570
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  16. NM_001384625.1 → NP_001371554.1  dipeptidyl peptidase 9 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 16, 17,19, and 20, encodes isoform 7.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92491.1
    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000469603.1, ENST00000598800.5
    Conserved Domains (2) summary
    pfam00326
    Location:662 → 863
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:146 → 570
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  17. NM_001384626.1 → NP_001371555.1  dipeptidyl peptidase 9 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 16-18 and 20, encodes isoform 7.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92491.1
    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:662 → 863
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:146 → 570
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  18. NM_001384627.1 → NP_001371556.1  dipeptidyl peptidase 9 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 16-19, encodes isoform 7.
    Source sequence(s)
    AC005594, AC005783
    Consensus CDS
    CCDS92491.1
    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:662 → 863
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:146 → 570
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  19. NM_001384628.1 → NP_001371557.1  dipeptidyl peptidase 9 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 22, encodes isoform 8.
    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    COG1506
    Location:533 → 822
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  20. NM_001384629.1 → NP_001371558.1  dipeptidyl peptidase 9 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variant 21, encodes isoform 8.
    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000515244.1, ENST00000703254.1
    Conserved Domains (2) summary
    COG1506
    Location:533 → 822
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  21. NM_001384630.1 → NP_001371559.1  dipeptidyl peptidase 9 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:678 → 843
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  22. NM_001384631.1 → NP_001371560.1  dipeptidyl peptidase 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:611 → 812
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 519
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  23. NM_001384632.1 → NP_001371561.1  dipeptidyl peptidase 9 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 26, encodes isoform 11.
    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:146 → 466
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  24. NM_001384633.1 → NP_001371562.1  dipeptidyl peptidase 9 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variant 25, encodes isoform 11.
    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:146 → 466
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  25. NM_001384634.1 → NP_001371563.1  dipeptidyl peptidase 9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 423
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  26. NM_001384635.1 → NP_001371564.1  dipeptidyl peptidase 9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 415
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  27. NM_001384636.1 → NP_001371565.1  dipeptidyl peptidase 9 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform 14.
    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 391
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  28. NM_001384637.1 → NP_001371566.1  dipeptidyl peptidase 9 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform 14.
    Source sequence(s)
    AC005594, AC005783
    Related
    ENST00000601764.5
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 391
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  29. NM_001384638.1 → NP_001371567.1  dipeptidyl peptidase 9 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform 14.
    Source sequence(s)
    AC005594, AC005783
    Conserved Domains (1) summary
    pfam00930
    Location:175 → 391
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  30. NM_139159.5 → NP_631898.3  dipeptidyl peptidase 9 isoform 1

    See identical proteins and their annotated locations for NP_631898.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AC005594, BC000970, BC037948, DB105598, DQ417928
    Consensus CDS
    CCDS45928.1
    UniProtKB/TrEMBL
    A0A8V8TR99
    Related
    ENSP00000262960.8, ENST00000262960.14
    Conserved Domains (2) summary
    pfam00326
    Location:691 → 892
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175 → 599
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RNA

  1. NR_158699.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  2. NR_169283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  3. NR_169284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  4. NR_169285.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  5. NR_169286.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  6. NR_169287.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  7. NR_169288.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  8. NR_169289.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  9. NR_169290.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  10. NR_169291.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

  11. NR_169292.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005594, AC005783

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4675227..4723842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528405.2 → XP_011526707.1  dipeptidyl peptidase 9 isoform X1

    See identical proteins and their annotated locations for XP_011526707.1

    UniProtKB/TrEMBL
    A0A8V8TR99
    Conserved Domains (2) summary
    pfam00326
    Location:745 → 946
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:229 → 653
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. XM_047439653.1 → XP_047295609.1  dipeptidyl peptidase 9 isoform X3

    UniProtKB/Swiss-Prot
    O75273, O75868, Q1ZZB8, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q86TI2, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3
    Related
    ENSP00000515514.1, ENST00000593973.2

  3. XM_047439652.1 → XP_047295608.1  dipeptidyl peptidase 9 isoform X2

  4. XM_047439654.1 → XP_047295610.1  dipeptidyl peptidase 9 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4659400..4708159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322557.1 → XP_054178532.1  dipeptidyl peptidase 9 isoform X1

  2. XM_054322558.1 → XP_054178533.1  dipeptidyl peptidase 9 isoform X2

  3. XM_054322559.1 → XP_054178534.1  dipeptidyl peptidase 9 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86TI2.3 GenPept UniProtKB/Swiss-Prot:Q86TI2

Gene LinkOut

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