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DEPDC7 DEP domain containing 7 [ Homo sapiens (human) ]

Gene ID: 91614, updated on 2-Nov-2024

Summary

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Official Symbol
DEPDC7provided by HGNC
Official Full Name
DEP domain containing 7provided by HGNC
Primary source
HGNC:HGNC:29899
See related
Ensembl:ENSG00000121690 MIM:612294; AllianceGenome:HGNC:29899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; dJ85M6.4
Summary
Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver (RPKM 15.2), testis (RPKM 15.0) and 9 other tissues See more
Orthologs
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Genomic context

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See DEPDC7 in Genome Data Viewer
Location:
11p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33015878..33033582)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33151462..33169161)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33037424..33055128)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 73 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:32912708-32913282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4568 Neighboring gene glutamine and serine rich 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32968504-32968654 Neighboring gene uncharacterized LOC105376615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33022947-33023448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33060521-33061068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:33071407-33071907 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33082368-33083567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33089797-33090298 Neighboring gene t-complex 11 like 1 Neighboring gene long intergenic non-protein coding RNA 294 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells. Liao Z, et al. Oncol Lett, 2017 Dec. PMID 29344171, Free PMC Article
  2. Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene. Liao Z, et al. Interdiscip Sci, 2017 Sep. PMID 27016254
  3. Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins. Córdova-Palomera A, et al. Eur Psychiatry, 2015 Sep. PMID 25952135
  4. The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation. D'Andrea EL, et al. PLoS One, 2014. PMID 25541973, Free PMC Article
  5. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. Gawin B, et al. Genome Res, 1999 Nov. PMID 10568747, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA interference (RNAi) recombinant lentiviral vector particle targeting DEPDC7 was constructed in order to knockdown its gene expression in human hepatocellular carcinoma cell line HepG2.
    Title: Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene.
  2. DEPDC7 hypomethylation in peripheral blood DNA may be associated with recent depressive symptomatology.
    Title: Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins.
  3. The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins.
    Title: The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
DEP domain-containing protein 7
Names
dJ85M6.4 (novel 58.3 KDA protein)
novel 58.3 KDA protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077242.2 → NP_001070710.1  DEP domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001070710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the more frequently occurring transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AJ245600, BC030970
    Consensus CDS
    CCDS41632.1
    UniProtKB/Swiss-Prot
    G5E941, Q8N602, Q8NCU9, Q96QD5, Q9UGK5
    Related
    ENSP00000241051.3, ENST00000241051.8
    Conserved Domains (2) summary
    cd04405
    Location:194 → 427
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cd04446
    Location:39 → 133
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.

  2. NM_139160.3 → NP_631899.2  DEP domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_631899.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a different segment for the 5' UTR and 5' CDS, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC107939, AJ245600, BC030970
    Consensus CDS
    CCDS41633.1
    UniProtKB/Swiss-Prot
    Q96QD5
    Related
    ENSP00000308971.3, ENST00000311388.7
    Conserved Domains (2) summary
    cd04405
    Location:185 → 418
    RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
    cd04446
    Location:30 → 124
    DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    33015878..33033582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    33151462..33169161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QD5.1 GenPept UniProtKB/Swiss-Prot:Q96QD5

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