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LSR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 9164871, updated on 11-Sep-2024

Summary

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Official Symbol
LSR1
Primary source
SGD:S000006478
Locus tag
YNCB0019C
See related
AllianceGenome:SGD:S000006478
Gene type
ncRNA
RNA name
snRNA
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pre-mRNA 5'-splice site binding activity. Involved in mRNA 5'-splice site recognition. Predicted to be part of U2 snRNP. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSR1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (680688..681862, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Om14p Neighboring gene Coq21p Neighboring gene Swc5p Neighboring gene Pbp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast. Kudla G, et al. Proc Natl Acad Sci U S A, 2011 Jun 14. PMID 21610164, Free PMC Article
  2. Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast. Smith DJ, et al. Mol Cell, 2009 May 15. PMID 19450531, Free PMC Article
  3. X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. Lin Y, et al. Biochemistry, 2008 May 20. PMID 18435545, Free PMC Article
  4. Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human. Sashital DG, et al. RNA, 2007 Mar. PMID 17242306, Free PMC Article
  5. Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing. McGrail JC, et al. EMBO J, 2006 Aug 23. PMID 16888626, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • U2 spliceosomal RNA (U2 snRNA), component of the spliceosome; pairs with the branchpoint sequence; functionally equivalent to mammalian U2 snRNA; stress-induced pseudouridylations at positions 56 and 93 contributes to regulation of splicing

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables pre-mRNA 5'-splice site binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA branch point binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 5'-splice site recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA branch site recognition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of U2 snRNP TAS
Traceable Author Statement
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    680688..681862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_132154.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

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Research Materials