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ZNF845 zinc finger protein 845 [ Homo sapiens (human) ]

Gene ID: 91664, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF845provided by HGNC
Official Full Name
zinc finger protein 845provided by HGNC
Primary source
HGNC:HGNC:25112
See related
Ensembl:ENSG00000213799 AllianceGenome:HGNC:25112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lymph node (RPKM 2.2), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF845 in Genome Data Viewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53333749..53356906)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56413246..56436414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53837002..53860159)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987270 Neighboring gene family with sequence similarity 90 member A28, pseudogene Neighboring gene vomeronasal 1 receptor 6, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53836118-53836982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15065 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene zinc finger protein 525 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  3. The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. Oravcová M, et al. Elife, 2022 Nov 14. PMID 36373674, Free PMC Article
  4. PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα. Ramberger E, et al. iScience, 2021 Jun 25. PMID 34189442, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 845

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321522.2 → NP_001308451.1  zinc finger protein 845

    Status: VALIDATED

    Source sequence(s)
    AC010467
    Consensus CDS
    CCDS46170.1
    UniProtKB/Swiss-Prot
    Q96IR2
    Conserved Domains (4) summary
    COG5048
    Location:381 → 813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:693 → 713
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:873 → 898
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321523.2 → NP_001308452.1  zinc finger protein 845

    Status: VALIDATED

    Source sequence(s)
    AC010467
    Consensus CDS
    CCDS46170.1
    UniProtKB/Swiss-Prot
    Q96IR2
    Conserved Domains (4) summary
    COG5048
    Location:381 → 813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:693 → 713
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:873 → 898
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001321524.2 → NP_001308453.1  zinc finger protein 845

    Status: VALIDATED

    Source sequence(s)
    AC010467
    Consensus CDS
    CCDS46170.1
    UniProtKB/Swiss-Prot
    Q96IR2
    Related
    ENSP00000470005.1, ENST00000595091.6
    Conserved Domains (4) summary
    COG5048
    Location:381 → 813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:693 → 713
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:873 → 898
    zf-H2C2_2; Zinc-finger double domain

  4. NM_138374.3 → NP_612383.1  zinc finger protein 845

    See identical proteins and their annotated locations for NP_612383.1

    Status: VALIDATED

    Source sequence(s)
    AC010467, DC400704
    Consensus CDS
    CCDS46170.1
    UniProtKB/Swiss-Prot
    Q96IR2
    Related
    ENSP00000388311.1, ENST00000458035.3
    Conserved Domains (4) summary
    COG5048
    Location:381 → 813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:693 → 713
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:873 → 898
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53333749..53356906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439677.1 → XP_047295633.1  zinc finger protein 845 isoform X1

    UniProtKB/Swiss-Prot
    Q96IR2
    Conserved Domains (4) summary
    COG5048
    Location:381 → 813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:693 → 713
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:873 → 898
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56413246..56436414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322608.1 → XP_054178583.1  zinc finger protein 845 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96IR2.3 GenPept UniProtKB/Swiss-Prot:Q96IR2

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