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ZMYM4 zinc finger MYM-type containing 4 [ Homo sapiens (human) ]

Gene ID: 9202, updated on 28-Oct-2024

Summary

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Official Symbol
ZMYM4provided by HGNC
Official Full Name
zinc finger MYM-type containing 4provided by HGNC
Primary source
HGNC:HGNC:13055
See related
Ensembl:ENSG00000146463 MIM:613568; AllianceGenome:HGNC:13055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM; CDIR; ZNF262; ZNF198L3
Summary
Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis (RPKM 15.0), ovary (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

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See ZMYM4 in Genome Data Viewer
Location:
1p34.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (35268709..35422058)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35131764..35285115)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35734310..35887659)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 637 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35658451-35659243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 725 Neighboring gene Sharpr-MPRA regulatory region 666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35676251-35676918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:35681555-35682151 Neighboring gene splicing factor proline and glutamine rich Neighboring gene ATAC-STARR-seq lymphoblastoid active region 726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:35738409-35738909 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35766904-35767102 Neighboring gene RNA, 7SL, cytoplasmic 503, pseudogene Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene NANOG hESC enhancer GRCh37_chr1:35827234-35827735 Neighboring gene ZMYM4 antisense RNA 1 Neighboring gene ribosomal protein L5 pseudogene 4 Neighboring gene MPRA-validated peak172 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:35855531-35856150 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:35856151-35856768 Neighboring gene KIAA0319 like Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35916701-35916880 Neighboring gene RNY5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 728 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35931229-35931375 Neighboring gene Sharpr-MPRA regulatory region 12145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 729 Neighboring gene zinc finger protein 485 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and Mutation Alterations of ZMYM4 Gene in Gastric and Colonic Cancers. Moon SW, et al. Appl Immunohistochem Mol Morphol, 2021 Sep 1. PMID 33938481
  2. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. Sohal J, et al. Cytogenet Cell Genet, 1999. PMID 10449923
  3. Cloning and mapping of members of the MYM family. Smedley D, et al. Genomics, 1999 Sep 1. PMID 10486218
  4. Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. Shchors K, et al. J Biol Chem, 2002 Dec 6. PMID 12356764
  5. Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins. Cibis H, et al. Sci Rep, 2020 May 21. PMID 32439918, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and Mutation Alterations of ZMYM4 Gene in Gastric and Colonic Cancers.
    Title: Expression and Mutation Alterations of ZMYM4 Gene in Gastric and Colonic Cancers.
  2. Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.
    Title: Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.
  3. regulates apoptosis by altering mRNA turnover and CDIR inhibits apoptosis by acting as a competitive inhibitor of AUF1, preventing AUF1 from binding to its targets
    Title: Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0425, DKFZp686L0547, DKFZp686B09210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
zinc finger MYM-type protein 4
Names
cell death inhibiting RNA
zinc finger protein 262
zinc finger, MYM-type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350138.2 → NP_001337067.1  zinc finger MYM-type protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BC127113, BG499626, BU683493
    Conserved Domains (3) summary
    smart00746
    Location:357 → 397
    TRASH; metallochaperone-like domain
    pfam06467
    Location:449 → 489
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1324 → 1493
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_001350139.2 → NP_001337068.1  zinc finger MYM-type protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
    UniProtKB/TrEMBL
    H7C1I7
    Conserved Domains (3) summary
    smart00746
    Location:65 → 105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157 → 197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1032 → 1201
    DUF3504; Domain of unknown function (DUF3504)

  3. NM_001350140.2 → NP_001337069.1  zinc finger MYM-type protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and lacks three consecutive exons, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC127113, BG499626, BU683493
    UniProtKB/TrEMBL
    H7C1I7
    Conserved Domains (3) summary
    smart00746
    Location:65 → 105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157 → 197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1032 → 1201
    DUF3504; Domain of unknown function (DUF3504)

  4. NM_001375653.1 → NP_001362582.1  zinc finger MYM-type protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL160000, AL356362, AL590434
    Conserved Domains (3) summary
    smart00746
    Location:392 → 432
    TRASH; metallochaperone-like domain
    pfam06467
    Location:484 → 524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1365 → 1529
    DUF3504; Domain of unknown function (DUF3504)

  5. NM_005095.3 → NP_005086.2  zinc finger MYM-type protein 4 isoform 1

    See identical proteins and their annotated locations for NP_005086.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
    Consensus CDS
    CCDS389.1
    UniProtKB/Swiss-Prot
    A0JP19, A0JP20, O43308, Q5T5E1, Q5T5E2, Q5VZL5, Q7L3Q4
    Related
    ENSP00000322915.6, ENST00000314607.11
    Conserved Domains (3) summary
    smart00746
    Location:389 → 429
    TRASH; metallochaperone-like domain
    pfam06467
    Location:478 → 521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1356 → 1525
    DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    35268709..35422058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002803.2 → XP_016858292.1  zinc finger MYM-type protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5VZL5
    Conserved Domains (3) summary
    smart00746
    Location:357 → 397
    TRASH; metallochaperone-like domain
    pfam06467
    Location:449 → 489
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1324 → 1493
    DUF3504; Domain of unknown function (DUF3504)

  2. XM_024450838.2 → XP_024306606.1  zinc finger MYM-type protein 4 isoform X4

    UniProtKB/TrEMBL
    H7C1I7
    Conserved Domains (3) summary
    smart00746
    Location:65 → 105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157 → 197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1032 → 1201
    DUF3504; Domain of unknown function (DUF3504)

  3. XM_047434271.1 → XP_047290227.1  zinc finger MYM-type protein 4 isoform X1

  4. XM_047434278.1 → XP_047290234.1  zinc finger MYM-type protein 4 isoform X4

  5. XM_047434282.1 → XP_047290238.1  zinc finger MYM-type protein 4 isoform X6

  6. XM_047434270.1 → XP_047290226.1  zinc finger MYM-type protein 4 isoform X1

  7. XM_005271331.3 → XP_005271388.1  zinc finger MYM-type protein 4 isoform X4

    See identical proteins and their annotated locations for XP_005271388.1

    UniProtKB/TrEMBL
    H7C1I7
    Conserved Domains (3) summary
    smart00746
    Location:65 → 105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157 → 197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1032 → 1201
    DUF3504; Domain of unknown function (DUF3504)

  8. XM_047434289.1 → XP_047290245.1  zinc finger MYM-type protein 4 isoform X6

  9. XM_047434269.1 → XP_047290225.1  zinc finger MYM-type protein 4 isoform X1

  10. XM_047434276.1 → XP_047290232.1  zinc finger MYM-type protein 4 isoform X3

  11. XM_047434274.1 → XP_047290230.1  zinc finger MYM-type protein 4 isoform X2

    Related
    ENSP00000400506.1, ENST00000457946.1

  12. XM_047434279.1 → XP_047290235.1  zinc finger MYM-type protein 4 isoform X5

RNA

  1. XR_246305.5 RNA Sequence

  2. XR_007064889.1 RNA Sequence

  3. XR_007064890.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    35131764..35285115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339605.1 → XP_054195580.1  zinc finger MYM-type protein 4 isoform X1

  2. XM_054339610.1 → XP_054195585.1  zinc finger MYM-type protein 4 isoform X4

  3. XM_054339604.1 → XP_054195579.1  zinc finger MYM-type protein 4 isoform X1

  4. XM_054339608.1 → XP_054195583.1  zinc finger MYM-type protein 4 isoform X4

  5. XM_054339612.1 → XP_054195587.1  zinc finger MYM-type protein 4 isoform X6

  6. XM_054339603.1 → XP_054195578.1  zinc finger MYM-type protein 4 isoform X1

  7. XM_054339609.1 → XP_054195584.1  zinc finger MYM-type protein 4 isoform X4

  8. XM_054339613.1 → XP_054195588.1  zinc finger MYM-type protein 4 isoform X6

  9. XM_054339602.1 → XP_054195577.1  zinc finger MYM-type protein 4 isoform X1

  10. XM_054339607.1 → XP_054195582.1  zinc finger MYM-type protein 4 isoform X3

  11. XM_054339606.1 → XP_054195581.1  zinc finger MYM-type protein 4 isoform X2

  12. XM_054339611.1 → XP_054195586.1  zinc finger MYM-type protein 4 isoform X5

RNA

  1. XR_008486206.1 RNA Sequence

  2. XR_008486207.1 RNA Sequence

  3. XR_008486208.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZL5.1 GenPept UniProtKB/Swiss-Prot:Q5VZL5

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