CD5 CD5 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD5provided by HGNC
Official Full Name: CD5 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1685
See related: Ensembl:ENSG00000110448 MIM:153340; AllianceGenome:HGNC:1685
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T1; LEU1
Summary: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Expression: Biased expression in lymph node (RPKM 19.1), appendix (RPKM 11.9) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (61093963..61127852)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (61045145..61079346)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (60861435..60895324)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD5: from antiquated T cell marker to immunotherapy's new hope.
Title: CD5: from antiquated T cell marker to immunotherapy's new hope.
CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8(+) T Cells by Inhibiting mTOR Pathways.
Title: CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8(+) T Cells by Inhibiting mTOR Pathways.
Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.
Title: Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.
T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape.
Title: T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape.
14-Color single tube for flow cytometric characterization of CD5+ B-LPDs and high sensitivity automated minimal residual disease quantitation of CLL/SLL.
Title: 14-Color single tube for flow cytometric characterization of CD5+ B-LPDs and high sensitivity automated minimal residual disease quantitation of CLL/SLL.
Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities.
Title: Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities.
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.
Title: Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.
diffuse large B-cell lymphoma (DLBCL) patients with DECM showed significantly inferior clinical outcomes compared to the CD5(+), MYC(+) or CD5(-)MYC(-) patients. Combinational therapeutic modalities might be a candidate approach to improve the prognosis of these patients.
Title: CD5(+)MYC(+) predicts worse prognosis in diffuse large B-cell lymphoma.
Two different anti-CD5- chimeric antigen receptors with costimulators 4-1BB and 2B4 (referred to as BB.z-natural killer (NK) cells and 2B4.z-NK, respectively) were constructed. 2B4.z-NK cells exhibited rapid proliferation and higher anti-malignant efficacy in both malignant CD5+ cell lines and primary CD5+ malignant cells in vitro through upregulation of activation markers and cytotoxic granule release.
Title: 2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies.
Study of four cases of pleomorphic mantle cell lymphoma with an immunophenotype of CD5(-) cyclin D1(-) SOX11(+) and morphologic features compatible with diffuse large B-cell lymphoma.
Title: Identification of CD5/Cyclin D1 Double-negative Pleomorphic Mantle Cell Lymphoma: A Clinicopathologic, Genetic, and Gene Expression Study.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD5	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-58041 (e-PCR)
- UniSTS:20012

GDB:197830 (e-PCR)
- UniSTS:155953

STS-X89405 (e-PCR)
- UniSTS:20116

CD5 (e-PCR), detects polymorphism
- UniSTS:11428

D11S4363 (e-PCR)
- UniSTS:27058

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell recognition	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: T-cell surface glycoprotein CD5

Names: CD5 antigen (p56-62); epididymis secretory sperm binding protein; lymphocyte antigen T1/Leu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346456.2 → NP_001333385.1 T-cell surface glycoprotein CD5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. This variant contains long terminal repeat (LTR) sequence and uses an alternate LTR promoter. The protein encoded lacks the leader peptide, compared to isoform 1 and represents an intracellular isoform found in a subset of B lymphocytes. (PMID: 15998834)

Source sequence(s)

AP000437, BC027901

UniProtKB/TrEMBL

H6D9U9
NM_014207.4 → NP_055022.2 T-cell surface glycoprotein CD5 isoform 1 precursor

See identical proteins and their annotated locations for NP_055022.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). The protein encoded represents an isoform found on the surface of T lymphocytes, B lymphocytes and thymocytes.

Source sequence(s)

AK292698, AP000437, BC027901, DB143341, X04391

Consensus CDS

CCDS8000.1

UniProtKB/Swiss-Prot

A0N0P4, A8K9I3, P06127

UniProtKB/TrEMBL

A0A384ME09

Related

ENSP00000342681.3, ENST00000347785.8

Conserved Domains (1) summary

smart00202
Location:36 → 133

SR; Scavenger receptor Cys-rich