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OXNAD1 oxidoreductase NAD binding domain containing 1 [ Homo sapiens (human) ]

Gene ID: 92106, updated on 3-Apr-2024

Summary

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Official Symbol
OXNAD1provided by HGNC
Official Full Name
oxidoreductase NAD binding domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25128
See related
Ensembl:ENSG00000154814 MIM:620581; AllianceGenome:HGNC:25128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 2.7), appendix (RPKM 1.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
3p25.1-p24.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (16265212..16352095)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (16266369..16353284)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (16306719..16393602)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16285879-16286378 Neighboring gene Sharpr-MPRA regulatory region 8904 Neighboring gene uncharacterized LOC124906218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16297189-16297690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14113 Neighboring gene diphthamide biosynthesis 3 Neighboring gene uncharacterized LOC107986065 Neighboring gene THAP domain containing 5 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14114 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16343021-16343602 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16343603-16344182 Neighboring gene Sharpr-MPRA regulatory region 2856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16377723-16378222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14115 Neighboring gene raftlin, lipid raft linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14116 Neighboring gene uncharacterized LOC124906220 Neighboring gene NANOG hESC enhancer GRCh37_chr3:16497386-16497905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19545 Neighboring gene uncharacterized LOC124906219 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16524187-16525039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Frequent DPH3 promoter mutations in skin cancers. Denisova E, et al. Oncotarget, 2015 Nov 3. PMID 26416425, Free PMC Article
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624, Free PMC Article
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  4. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Shami Shah A, et al. Cell Rep, 2019 May 14. PMID 31091453, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
oxidoreductase NAD-binding domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330670.3 → NP_001317599.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090953, BC007285
    Consensus CDS
    CCDS87053.1
    UniProtKB/TrEMBL
    B4DQJ7, C9JLB7, F5H620
    Related
    ENSP00000487136.1, ENST00000627468.2
    Conserved Domains (1) summary
    cd00322
    Location:93 → 327
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  2. NM_001330671.3 → NP_001317600.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, CR739022
    Consensus CDS
    CCDS87053.1
    UniProtKB/TrEMBL
    B4DQJ7, C9JLB7, F5H620
    Related
    ENSP00000389872.2, ENST00000435829.6
    Conserved Domains (1) summary
    cd00322
    Location:93 → 327
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  3. NM_001352977.2 → NP_001339906.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, BQ180851
    Consensus CDS
    CCDS2630.1
    UniProtKB/Swiss-Prot
    Q2HYC7, Q59FA4, Q96HP4
    UniProtKB/TrEMBL
    U3KQU8
    Related
    ENSP00000476239.1, ENST00000606098.1
    Conserved Domains (1) summary
    cd00322
    Location:75 → 309
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  4. NM_001352978.2 → NP_001339907.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, CR739022
    Consensus CDS
    CCDS2630.1
    UniProtKB/Swiss-Prot
    Q2HYC7, Q59FA4, Q96HP4
    UniProtKB/TrEMBL
    U3KQU8
    Related
    ENSP00000475547.1, ENST00000605932.5
    Conserved Domains (1) summary
    cd00322
    Location:75 → 309
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  5. NM_001352980.2 → NP_001339909.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090953, BC007285
    UniProtKB/TrEMBL
    U3KQU8
    Conserved Domains (1) summary
    cd00322
    Location:48 → 282
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  6. NM_001352981.2 → NP_001339910.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, BQ180851
    UniProtKB/TrEMBL
    U3KQU8
    Conserved Domains (1) summary
    cd00322
    Location:48 → 282
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  7. NM_001352982.2 → NP_001339911.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953
    UniProtKB/TrEMBL
    U3KQU8
    Conserved Domains (1) summary
    cd00322
    Location:48 → 282
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  8. NM_001352983.2 → NP_001339912.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, CR739022
    UniProtKB/TrEMBL
    U3KQU8
    Conserved Domains (1) summary
    cd00322
    Location:48 → 282
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  9. NM_138381.5 → NP_612390.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_612390.1

    Status: VALIDATED

    Source sequence(s)
    AC090953, BC007285, BC008322, HY044078
    Consensus CDS
    CCDS2630.1
    UniProtKB/Swiss-Prot
    Q2HYC7, Q59FA4, Q96HP4
    UniProtKB/TrEMBL
    U3KQU8
    Related
    ENSP00000285083.5, ENST00000285083.10
    Conserved Domains (1) summary
    cd00322
    Location:75 → 309
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RNA

  1. NR_148217.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, BQ180851

  2. NR_148218.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, BQ180851

  3. NR_148219.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, BQ180851

  4. NR_148220.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090948, AC090953, CR739022

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    16265212..16352095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534230.4 → XP_011532532.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011532532.1

    UniProtKB/TrEMBL
    B4DQJ7
    Conserved Domains (1) summary
    cd00322
    Location:148 → 382
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  2. XM_011534235.4 → XP_011532537.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011532537.1

    UniProtKB/TrEMBL
    B4DQJ7
    Conserved Domains (1) summary
    cd00322
    Location:148 → 382
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  3. XM_005265559.5 → XP_005265616.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005265616.1

    UniProtKB/TrEMBL
    B4DQJ7
    Conserved Domains (1) summary
    cd00322
    Location:148 → 382
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RNA

  1. XR_007095766.1 RNA Sequence

  2. XR_007095767.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    16266369..16353284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348411.1 → XP_054204386.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

  2. XM_054348412.1 → XP_054204387.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

  3. XM_054348413.1 → XP_054204388.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

RNA

  1. XR_008486850.1 RNA Sequence

  2. XR_008486851.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96HP4.1 GenPept UniProtKB/Swiss-Prot:Q96HP4

Gene LinkOut

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