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TMEM88 transmembrane protein 88 [ Homo sapiens (human) ]

Gene ID: 92162, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM88provided by HGNC
Official Full Name
transmembrane protein 88provided by HGNC
Primary source
HGNC:HGNC:32371
See related
Ensembl:ENSG00000167874 MIM:617813; AllianceGenome:HGNC:32371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 7.7), placenta (RPKM 7.1) and 23 other tissues See more
Orthologs
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Genomic context

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See TMEM88 in Genome Data Viewer
Location:
17p13.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7855066..7856099)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7760392..7761425)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7758384..7759417)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7742757-7743257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8143 Neighboring gene lysine demethylase 6B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11647 Neighboring gene uncharacterized LOC107987244 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr17:7754177-7755141 and GRCh37_chr17:7755142-7756105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7756106-7757070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7759303-7759840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7760574-7761436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7761437-7762298 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7792539-7793108 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:7797066-7798265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806009-7806616 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806617-7807223 Neighboring gene small Cajal body-specific RNA 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway. Sun Z, et al. J Recept Signal Transduct Res, 2022 Feb. PMID 33167758
  2. Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling. Geng Q, et al. Exp Cell Res, 2020 Oct 15. PMID 32710906
  3. TMEM88 inhibits extracellular matrix expression in keloid fibroblasts. Zhao H, et al. Biomed Pharmacother, 2017 Nov. PMID 28946191
  4. Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. de Leon M, et al. Gynecol Oncol, 2016 Sep. PMID 27374141, Free PMC Article
  5. TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/β-catenin signaling. Zhao X, et al. J Biochem Mol Toxicol, 2021 Aug. PMID 34057764

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane protein 88 inhibits transforming growth factor-beta1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-beta1/Smad pathway.
    Title: Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway.
  2. TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/beta-catenin signaling.
    Title: TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/β-catenin signaling.
  3. MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88.
    Title: MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88.
  4. Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/beta-catenin signaling.
    Title: Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling.
  5. TMEM88 plays a significant role in TNF-alpha-enhanced cytokine (IL-6 and IL-1beta) secretion of LX-2 cells via regulating JNK/P38 and canonical Wnt/beta-catenin signaling pathway.
    Title: TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells.
  6. TMEM88 inhibits the TGF-beta1-stimulated cell proliferation, migration and extracellular matrix expression in keloid fibroblasts.
    Title: TMEM88 inhibits extracellular matrix expression in keloid fibroblasts.
  7. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival
    Title: TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.
  8. Results support that OC platinum resistance was correlated with TMEM88 overexpression regulated through decreased promoter methylation. Data suggest that TMEM88 functions as an inhibitor of Wnt signaling, contributing to the development of platinum resistance.
    Title: Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer.
  9. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVL1.
    Title: Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl.
  10. mislocalization of TMEM88 to the cytosol in non-small cell lung cancer cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3beta-Snail signaling pathway.
    Title: Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20025, MGC71744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein stabilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319941.1 → NP_001306870.1  transmembrane protein 88 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC104581
    Consensus CDS
    CCDS82058.1
    UniProtKB/TrEMBL
    I3L2J3
    Related
    ENSP00000459725.1, ENST00000574668.1

  2. NM_203411.2 → NP_981956.1  transmembrane protein 88 isoform 1

    See identical proteins and their annotated locations for NP_981956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC057812
    Consensus CDS
    CCDS11121.1
    UniProtKB/Swiss-Prot
    Q6PEY1
    Related
    ENSP00000301599.6, ENST00000301599.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7855066..7856099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256856.4 → XP_005256913.1  transmembrane protein 88 isoform X1

    See identical proteins and their annotated locations for XP_005256913.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7760392..7761425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317780.1 → XP_054173755.1  transmembrane protein 88 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEY1.1 GenPept UniProtKB/Swiss-Prot:Q6PEY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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