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BICDL1 BICD family like cargo adaptor 1 [ Homo sapiens (human) ]

Gene ID: 92558, updated on 2-Nov-2024

Summary

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Official Symbol
BICDL1provided by HGNC
Official Full Name
BICD family like cargo adaptor 1provided by HGNC
Primary source
HGNC:HGNC:28095
See related
Ensembl:ENSG00000135127 MIM:617002; AllianceGenome:HGNC:28095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BICDR1; CCDC64; BICDR-1; CCDC64A; H_267D11.1
Summary
Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport; neuron projection development; and vesicle transport along microtubule. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney (RPKM 26.8), skin (RPKM 12.5) and 9 other tissues See more
Orthologs
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Genomic context

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See BICDL1 in Genome Data Viewer
Location:
12q24.23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119989236..120094495)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119976368..120081656)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120427040..120532299)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene citron rho-interacting serine/threonine kinase Neighboring gene microRNA 1178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120185956-120187155 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120192166-120192349 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120197803-120197989 Neighboring gene NANOG hESC enhancer GRCh37_chr12:120213039-120213640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120242131-120242682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120306702-120307901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4931 Neighboring gene uncharacterized LOC112268087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7119 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120423527-120423708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120426711-120427684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120427685-120428656 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120431757-120431860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7120 Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120490668-120490841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120528583-120529175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120530601-120531244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120531245-120531888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120540395-120540996 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120540997-120541598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120541599-120542200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120542201-120542802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120556125-120556916 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120555445-120555623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4941 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120554541-120555332 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120553748-120554540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120548255-120548774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120547737-120548254 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120547217-120547736 Neighboring gene RAB35 antisense RNA 1 Neighboring gene RAB35, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding. Hoogenraad CC, et al. Trends Cell Biol, 2016 May. PMID 26822037
  2. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
  3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545, Free PMC Article
  4. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. Warnatz HJ, et al. J Biol Chem, 2011 Jul 1. PMID 21555518, Free PMC Article
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC64 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
    Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynactin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi to secretory granule transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to secretory granule transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BICD family-like cargo adapter 1
Names
BICD-related protein 1
bicaudal D-related protein 1
coiled-coil domain containing 64
coiled-coil domain-containing protein 64A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367886.1 → NP_001354815.1  BICD family-like cargo adapter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815
    Consensus CDS
    CCDS91757.1
    UniProtKB/TrEMBL
    H0YHP2
    Related
    ENSP00000447477.2, ENST00000548673.6

  2. NM_207311.2 → NP_997194.2  BICD family-like cargo adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_997194.2

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815, AK129960, U88834
    Consensus CDS
    CCDS41845.1
    UniProtKB/Swiss-Prot
    A8MUC8, B4DWL0, B5MDJ0, O95000, Q6ZP65
    Related
    ENSP00000380690.2, ENST00000397558.6
    Conserved Domains (2) summary
    pfam14988
    Location:120 → 296
    DUF4515; Domain of unknown function (DUF4515)
    cl19252
    Location:167 → 295
    MreC; rod shape-determining protein MreC

RNA

  1. NR_147892.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815

  2. NR_147893.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815

  3. NR_147894.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    119989236..120094495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719694.4 → XP_006719757.1  BICD family-like cargo adapter 1 isoform X1

    Conserved Domains (2) summary
    pfam14988
    Location:120 → 300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164 → 279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_006719696.4 → XP_006719759.1  BICD family-like cargo adapter 1 isoform X5

    Conserved Domains (2) summary
    pfam14988
    Location:120 → 300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164 → 279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_006719697.4 → XP_006719760.1  BICD family-like cargo adapter 1 isoform X7

    Conserved Domains (2) summary
    pfam01665
    Location:99 → 264
    Rota_NSP3; Rotavirus non-structural protein NSP3
    pfam14988
    Location:120 → 300
    DUF4515; Domain of unknown function (DUF4515)

  4. XM_047429890.1 → XP_047285846.1  BICD family-like cargo adapter 1 isoform X8

  5. XM_047429887.1 → XP_047285843.1  BICD family-like cargo adapter 1 isoform X3

  6. XM_011538999.3 → XP_011537301.1  BICD family-like cargo adapter 1 isoform X2

    Conserved Domains (2) summary
    pfam14988
    Location:120 → 300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164 → 279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  7. XM_047429889.1 → XP_047285845.1  BICD family-like cargo adapter 1 isoform X6

  8. XM_047429888.1 → XP_047285844.1  BICD family-like cargo adapter 1 isoform X4

  9. XM_011539000.2 → XP_011537302.1  BICD family-like cargo adapter 1 isoform X9

    See identical proteins and their annotated locations for XP_011537302.1

    Conserved Domains (1) summary
    TIGR02168
    Location:54 → 379
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_047429891.1 → XP_047285847.1  BICD family-like cargo adapter 1 isoform X10

RNA

  1. XR_007063143.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    119976368..120081656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373843.1 → XP_054229818.1  BICD family-like cargo adapter 1 isoform X1

  2. XM_054373847.1 → XP_054229822.1  BICD family-like cargo adapter 1 isoform X5

  3. XM_054373849.1 → XP_054229824.1  BICD family-like cargo adapter 1 isoform X7

  4. XM_054373850.1 → XP_054229825.1  BICD family-like cargo adapter 1 isoform X8

  5. XM_054373845.1 → XP_054229820.1  BICD family-like cargo adapter 1 isoform X3

  6. XM_054373844.1 → XP_054229819.1  BICD family-like cargo adapter 1 isoform X2

  7. XM_054373848.1 → XP_054229823.1  BICD family-like cargo adapter 1 isoform X6

  8. XM_054373846.1 → XP_054229821.1  BICD family-like cargo adapter 1 isoform X4

  9. XM_054373851.1 → XP_054229826.1  BICD family-like cargo adapter 1 isoform X9

  10. XM_054373852.1 → XP_054229827.1  BICD family-like cargo adapter 1 isoform X10

RNA

  1. XR_008488711.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZP65.2 GenPept UniProtKB/Swiss-Prot:Q6ZP65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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