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OPG083 Viral core cysteine proteinase [ Monkeypox virus ]

Gene ID: 929056, updated on 31-Jan-2024

Summary

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Gene symbol
OPG083
Gene description
Viral core cysteine proteinase
Locus tag
MPXV_gp063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Monkeypox virus (strain: Zaire-96-I-16, nat-host: Homo sapiens)
Lineage
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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Genomic context

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Sequence:
NC_003310.1 (65719..66990, complement)

NC_003310.1Genomic Context describing neighboring genes Neighboring gene Ribonucleoside-diphosphate reductase (2) Neighboring gene IMV membrane protein I5 Neighboring gene Telomere-binding protein Neighboring gene RNA helicase NPH-II (2) Neighboring gene Metalloendopeptidase Neighboring gene Entry/fusion complex component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003310.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human monkeypox and smallpox viruses: genomic comparison. Shchelkunov SN, et al. FEBS Lett, 2001 Nov 30. PMID 11734207, Free PMC Article
  2. Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes. Senkevich TG, et al. mBio, 2021 Aug 31. PMID 34253028, Free PMC Article
  3. Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO). Zmasek CM, et al. Virology, 2019 Mar. PMID 30660046, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
Viral core cysteine proteinase
NP_536495.1
  • Taxonomic breadth: chordopoxvirinae; Old product: I7L; virion core protein; similar to DNA topoisomerase II; Virion core cysteine protease; similar to VACV-WR I7L and VACV-Cop I7L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003310.1 Reference assembly

    Range
    65719..66990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_536495.1 Viral core cysteine proteinase [Monkeypox virus]

    See identical proteins and their annotated locations for NP_536495.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0F6N6K4, A0A650BUM0, A0A7H0DR92, F1DIS5, M1L4Z8, Q3I7P9, Q5IXV7, Q8V512
    Conserved Domains (1) summary
    pfam03290
    Location:1 → 420
    Peptidase_C57; Vaccinia virus I7 processing peptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAL40526.1

Gene LinkOut

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