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CADPS2 calcium dependent secretion activator 2 [ Homo sapiens (human) ]

Gene ID: 93664, updated on 3-Apr-2024

Summary

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Official Symbol
CADPS2provided by HGNC
Official Full Name
calcium dependent secretion activator 2provided by HGNC
Primary source
HGNC:HGNC:16018
See related
Ensembl:ENSG00000081803 MIM:609978; AllianceGenome:HGNC:16018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPS2
Summary
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in kidney (RPKM 9.9), brain (RPKM 7.6) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q31.32
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (122318411..122886460, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (123634402..124203026, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (121958465..122526514, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 37 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121924115-121924720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951480-121951992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121951993-121952505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:121955253-121955783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:121956930-121957784 Neighboring gene VISTA enhancer hs1809 Neighboring gene FEZF1 antisense RNA 1 Neighboring gene FEZ family zinc finger 1 Neighboring gene NANOG hESC enhancer GRCh37_chr7:122088873-122089630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167222-122167722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122167723-122168223 Neighboring gene uncharacterized LOC105375481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:122319235-122319791 Neighboring gene uncharacterized LOC124901739 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:122332441-122332940 Neighboring gene uncharacterized LOC124901738 Neighboring gene ribosomal protein S26 pseudogene 31 Neighboring gene ring finger protein 133 Neighboring gene ring finger protein 148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:122458991-122459843 Neighboring gene RELA proto-oncogene, NF-kB subunit pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122553388-122553898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122553899-122554408 Neighboring gene uncharacterized LOC105375482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:122572022-122572522 Neighboring gene NANOG hESC enhancer GRCh37_chr7:122627466-122627971 Neighboring gene taste 2 receptor member 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Maternally inherited genetic variants of CADPS2 are present in autism spectrum disorders and intellectual disability patients. Bonora E, et al. EMBO Mol Med, 2014 Jun. PMID 24737869, Free PMC Article
  2. Blood CADPS2ΔExon3 expression is associated with intelligence and memory in healthy adults. Hattori K, et al. Biol Psychol, 2012 Jan. PMID 22001167
  3. Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. Zhang K, et al. World J Biol Psychiatry, 2019 Jul. PMID 28971736, Free PMC Article
  4. Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV. Okamoto N, et al. Am J Med Genet A, 2011 Jul. PMID 21626674
  5. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. Sadakata T, et al. J Clin Invest, 2007 Apr. PMID 17380209, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
    Title: Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
  2. The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function.
    Title: Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level.
  3. These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.
    Title: CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.
  4. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR interaction.
    Title: Maternally inherited genetic variants of CADPS2 are present in autism spectrum disorders and intellectual disability patients.
  5. This study suggested that CADPS2DeltaExon3 affects intelligence and memory in the non-clinical population.
    Title: Blood CADPS2ΔExon3 expression is associated with intelligence and memory in healthy adults.
  6. We speculate that haploinsufficiency of CADPS2 contributes to ASDs.
    Title: Submicroscopic deletion in 7q31 encompassing CADPS2 and TSPAN12 in a child with autism spectrum disorder and PHPV.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Voxelwise genome-wide association study (vGWAS).
  9. Genetic disturbance in CADPS2-mediated neurotrophin release contributes to autism susceptibility.
    Title: Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.
  10. CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2
    Title: Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-07-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-07-10)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Voxelwise genome-wide association study (vGWAS).
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40851, KIAA1591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium-dependent secretion activator 2
Names
CAPS-2
Ca++-dependent secretion activator 2
Ca2+ dependent secretion activator 2
Ca2+-dependent activator protein for secretion 2
calcium-dependent activator protein for secretion 2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016215.2 RefSeqGene

    Range
    5300..573349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009571.4 → NP_001009571.2  calcium-dependent secretion activator 2 isoform b

    See identical proteins and their annotated locations for NP_001009571.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate in-frame exons and includes an alternate in-frame exon, compared to variant 3. The resulting isoform (b) differs in four regions and is shorter compared to isoform c.
    Source sequence(s)
    AB046811, AC015983, AF401638, BX110721, DA248542
    Consensus CDS
    CCDS47691.1
    UniProtKB/TrEMBL
    X5DNG0, X5DQT2
    Related
    ENSP00000400401.2, ENST00000412584.6
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:798 → 888
    DUF1041; Domain of Unknown Function (DUF1041)

  2. NM_001167940.2 → NP_001161412.1  calcium-dependent secretion activator 2 isoform c

    See identical proteins and their annotated locations for NP_001161412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC015983, AF401638, BC144279, BX110721, DA248542
    UniProtKB/TrEMBL
    B7ZM57, X5DQT2
    Related
    ENSP00000325581.8, ENST00000313070.11
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  3. NM_001363389.2 → NP_001350318.1  calcium-dependent secretion activator 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AB046811, AC006463, AC015983, BP376175, BX110721, DA060101, DA210803, DA248542, KJ534803
    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 901
    DUF1041; Domain of Unknown Function (DUF1041)

  4. NM_001363390.2 → NP_001350319.1  calcium-dependent secretion activator 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC006463, AC015983, AK054853, BX110721, DA210803, DA248542, KJ534803
    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 901
    DUF1041; Domain of Unknown Function (DUF1041)

  5. NM_001363391.2 → NP_001350320.1  calcium-dependent secretion activator 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC006463, AC015983, AK054853, BP378689, BX110721, DA041479, DA210803, DA248542, KJ534803
    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:798 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  6. NM_001363392.2 → NP_001350321.1  calcium-dependent secretion activator 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AB046811, AC006463, AC015983, BP376175, BX110721, DA210803, DA248542, DT220064, KJ534803
    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 901
    DUF1041; Domain of Unknown Function (DUF1041)

  7. NM_001363393.2 → NP_001350322.1  calcium-dependent secretion activator 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AB046811, AC006463, AC015983, BX110721, DA248542, KJ534803, KJ534804
    UniProtKB/TrEMBL
    X5D2D9, X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 901
    DUF1041; Domain of Unknown Function (DUF1041)

  8. NM_001363394.2 → NP_001350323.1  calcium-dependent secretion activator 2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AB046811, AC004594, AC006463, AC015983, BX110721, DA248542, KJ534803
    UniProtKB/TrEMBL
    X5D8X0, X5DQT2
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  9. NM_001363395.2 → NP_001350324.1  calcium-dependent secretion activator 2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:798 → 895
    DUF1041; Domain of Unknown Function (DUF1041)

  10. NM_001363396.2 → NP_001350325.1  calcium-dependent secretion activator 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC006463, AC015983, AK054853, BX110721, DA248542, KJ534798, KJ534803
    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 894
    DUF1041; Domain of Unknown Function (DUF1041)

  11. NM_001363397.2 → NP_001350326.1  calcium-dependent secretion activator 2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AB046811, AC004594, AC006463, AC015983, BX110721, DA248542, KJ534802, KJ534803
    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:801 → 891
    DUF1041; Domain of Unknown Function (DUF1041)

  12. NM_001363398.2 → NP_001350327.1  calcium-dependent secretion activator 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC015983, AK054853, BX110721, DA248542, KJ534805
    UniProtKB/TrEMBL
    X5D7B2, X5DQT2
    Conserved Domains (3) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:798 → 888
    DUF1041; Domain of Unknown Function (DUF1041)

  13. NM_001363399.2 → NP_001350328.1  calcium-dependent secretion activator 2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
    UniProtKB/TrEMBL
    F8W8P5
    Conserved Domains (3) summary
    smart00239
    Location:205 → 287
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:320 → 439
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:640 → 740
    DUF1041; Domain of Unknown Function (DUF1041)

  14. NM_001363400.2 → NP_001350329.1  calcium-dependent secretion activator 2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC004594, AC004838, AC006009, AC006463, AC015983, AC091438
    UniProtKB/TrEMBL
    F8W8P5
    Conserved Domains (3) summary
    smart00239
    Location:205 → 287
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:320 → 439
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:640 → 740
    DUF1041; Domain of Unknown Function (DUF1041)

  15. NM_017954.11 → NP_060424.9  calcium-dependent secretion activator 2 isoform a

    See identical proteins and their annotated locations for NP_060424.9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 3. The resulting isoform (a) differs in two regions and is shorter compared to isoform c.
    Source sequence(s)
    AB046811, AC015983, AY264289, BC144278, BX110721, DA248542
    Consensus CDS
    CCDS55158.1
    UniProtKB/Swiss-Prot
    A4D0X3, B7ZM56, Q658Q2, Q7Z5T7, Q86UW7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
    UniProtKB/TrEMBL
    X5D8W6
    Related
    ENSP00000398481.2, ENST00000449022.7
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 894
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    122318411..122886460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421032.1 → XP_047276988.1  calcium-dependent secretion activator 2 isoform X8

  2. XM_017012794.3 → XP_016868283.1  calcium-dependent secretion activator 2 isoform X6

    UniProtKB/TrEMBL
    X5DQT2

  3. XM_005250702.6 → XP_005250759.1  calcium-dependent secretion activator 2 isoform X7

    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:798 → 891
    DUF1041; Domain of Unknown Function (DUF1041)

  4. XM_047421031.1 → XP_047276987.1  calcium-dependent secretion activator 2 isoform X4

  5. XM_047421033.1 → XP_047276989.1  calcium-dependent secretion activator 2 isoform X10

  6. XM_005250706.6 → XP_005250763.1  calcium-dependent secretion activator 2 isoform X11

    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:798 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  7. XM_005250697.6 → XP_005250754.1  calcium-dependent secretion activator 2 isoform X1

    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:798 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  8. XM_005250707.6 → XP_005250764.1  calcium-dependent secretion activator 2 isoform X12

    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 891
    DUF1041; Domain of Unknown Function (DUF1041)

  9. XM_005250701.6 → XP_005250758.1  calcium-dependent secretion activator 2 isoform X5

    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 891
    DUF1041; Domain of Unknown Function (DUF1041)

  10. XM_005250699.6 → XP_005250756.1  calcium-dependent secretion activator 2 isoform X3

    UniProtKB/TrEMBL
    X5D8W6
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 894
    DUF1041; Domain of Unknown Function (DUF1041)

  11. XM_005250704.6 → XP_005250761.1  calcium-dependent secretion activator 2 isoform X9

    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  12. XM_005250696.6 → XP_005250753.1  calcium-dependent secretion activator 2 isoform X2

    UniProtKB/TrEMBL
    X5DQT2
    Conserved Domains (4) summary
    smart00239
    Location:366 → 448
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:481 → 600
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:489 → 588
    PH; PH domain
    pfam06292
    Location:801 → 898
    DUF1041; Domain of Unknown Function (DUF1041)

  13. XM_017012796.3 → XP_016868285.1  calcium-dependent secretion activator 2 isoform X13

    UniProtKB/TrEMBL
    F8W8P5

  14. XM_047421034.1 → XP_047276990.1  calcium-dependent secretion activator 2 isoform X14

    Related
    ENSP00000380833.4, ENST00000397721.4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    123634402..124203026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359340.1 → XP_054215315.1  calcium-dependent secretion activator 2 isoform X8

  2. XM_054359338.1 → XP_054215313.1  calcium-dependent secretion activator 2 isoform X6

  3. XM_054359339.1 → XP_054215314.1  calcium-dependent secretion activator 2 isoform X7

  4. XM_054359336.1 → XP_054215311.1  calcium-dependent secretion activator 2 isoform X4

  5. XM_054359342.1 → XP_054215317.1  calcium-dependent secretion activator 2 isoform X10

  6. XM_054359343.1 → XP_054215318.1  calcium-dependent secretion activator 2 isoform X11

  7. XM_054359333.1 → XP_054215308.1  calcium-dependent secretion activator 2 isoform X1

  8. XM_054359344.1 → XP_054215319.1  calcium-dependent secretion activator 2 isoform X12

  9. XM_054359337.1 → XP_054215312.1  calcium-dependent secretion activator 2 isoform X5

  10. XM_054359335.1 → XP_054215310.1  calcium-dependent secretion activator 2 isoform X3

  11. XM_054359341.1 → XP_054215316.1  calcium-dependent secretion activator 2 isoform X9

  12. XM_054359334.1 → XP_054215309.1  calcium-dependent secretion activator 2 isoform X2

  13. XM_054359345.1 → XP_054215320.1  calcium-dependent secretion activator 2 isoform X13

  14. XM_054359346.1 → XP_054215321.1  calcium-dependent secretion activator 2 isoform X14

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UW7.2 GenPept UniProtKB/Swiss-Prot:Q86UW7

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