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RAB9A RAB9A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 9367, updated on 5-Mar-2024

Summary

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Official Symbol
RAB9Aprovided by HGNC
Official Full Name
RAB9A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9792
See related
Ensembl:ENSG00000123595 MIM:300284; AllianceGenome:HGNC:9792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB9
Summary
Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xp22.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (13689128..13710504)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (13270511..13291900)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (13707247..13728623)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13671061-13671372 Neighboring gene uncharacterized LOC107985657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29442 Neighboring gene uncharacterized LOC107985656 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:13687079-13688278 Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20668 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13710181-13710377 Neighboring gene trafficking protein particle complex subunit 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:13752241-13753440 Neighboring gene OFD1 centriole and centriolar satellite protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:13778869-13779368 Neighboring gene glycoprotein M6B Neighboring gene NANOG hESC enhancer GRCh37_chrX:13820205-13820738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:13845691-13846890

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells. Sun P, et al. Biomed Res Int, 2020. PMID 32420351, Free PMC Article
  2. Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway. Zhu Y, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 32301398, Free PMC Article
  3. Rab9A is required for delivery of cargo from recycling endosomes to melanosomes. Mahanty S, et al. Pigment Cell Melanoma Res, 2016 Jan. PMID 26527546, Free PMC Article
  4. Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells. Barbero P, et al. J Cell Biol, 2002 Feb 4. PMID 11827983, Free PMC Article
  5. Rab GDI: a solubilizing and recycling factor for rab9 protein. Soldati T, et al. Mol Biol Cell, 1993 Apr. PMID 8389620, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
    Title: Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
  2. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
    Title: Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
  3. Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
    Title: Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
  4. RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
    Title: RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
  5. Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
    Title: Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
  6. Authors predicted the binding between RAB9A and miR-150-5p, and the direct interaction between RAB9A and miR-150-5p was confirmed by luciferase reporter and RNA immunoprecipitation assays. We also showed that RAB9A expression was regulated negatively by miR-150-5p, but was regulated positively by ZFAS1.
    Title: Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.
  7. RAB9 competes with the catalytic subunit PPP2CA in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A catalytic activity.
    Title: A subset of RAB proteins modulates PP2A phosphatase activity.
  8. protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off.
    Title: Protein Kinase C Activation Promotes α(1B)-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization.
  9. Rab9A and its co-regulatory GTPases control STX13-mediated cargo delivery to maturing melanosomes.
    Title: Rab9A is required for delivery of cargo from recycling endosomes to melanosomes.
  10. Rab9-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles.
    Title: TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of RAB9A, member RAS oncogene family (RAB9A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef disrupts Rab9-GCC2 interaction (in HEK-293 cells) resulting in delocalization of CI-MPR resulting in elevated secretion of hexosaminidase in HEK-293 cells PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation by host of symbiont catalytic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
  
located_in transport vesicle TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ras-related protein Rab-9A
Names
RAB9, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195328.2 → NP_001182257.1  ras-related protein Rab-9A

    See identical proteins and their annotated locations for NP_001182257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC003037, AK290505, BC017265, CF528703, DA141710
    Consensus CDS
    CCDS14156.1
    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1
    Related
    ENSP00000480777.1, ENST00000618931.2
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)

  2. NM_004251.5 → NP_004242.1  ras-related protein Rab-9A

    See identical proteins and their annotated locations for NP_004242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC003037, BC017265, CF528703, DA141710
    Consensus CDS
    CCDS14156.1
    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1
    Related
    ENSP00000420127.1, ENST00000464506.2
    Conserved Domains (1) summary
    cd04116
    Location:3 → 172
    Rab9; Rab GTPase family 9 (Rab9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    13689128..13710504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442645.1 → XP_047298601.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1

  2. XM_047442644.1 → XP_047298600.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    13270511..13291900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328136.1 → XP_054184111.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1

  2. XM_054328135.1 → XP_054184110.1  ras-related protein Rab-9A isoform X1

    UniProtKB/Swiss-Prot
    A8K390, P51151, Q6ICN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51151.1 GenPept UniProtKB/Swiss-Prot:P51151

Gene LinkOut

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