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Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 [ Mus musculus (house mouse) ]

Gene ID: 93674, updated on 28-Oct-2024

Summary

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Official Symbol
Nat8f3provided by MGI
Official Full Name
N-acetyltransferase 8 (GCN5-related) family member 3provided by MGI
Primary source
MGI:MGI:2136449
See related
Ensembl:ENSMUSG00000051262 AllianceGenome:MGI:2136449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cml3; 4833414A14Rik; 4930583K21Rik
Summary
Enables histone H4 acetyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within axis elongation and negative regulation of cell adhesion. Located in nuclear membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in kidney adult (RPKM 106.4) and bladder adult (RPKM 4.7) See more
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Genomic context

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See Nat8f3 in Genome Data Viewer
Location:
6 C3; 6 37.48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85737613..85742726, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85760631..85765767, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16506 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7 Neighboring gene ALMS1, centrosome and basal body associated, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_16507 Neighboring gene ALMS1, centrosome and basal body associated, pseudogene 2 Neighboring gene microRNA 6375

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Kimura A, et al. Cell, 1986 Jan 31. PMID 3510743
  2. Camello, a novel family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish development. Karmodiya K, et al. Sci Rep, 2014 Aug 15. PMID 25123547, Free PMC Article
  3. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, et al. Dev Biol, 2001 Jun 15. PMID 11397015
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables cysteine-S-conjugate N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axis elongation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in gastrulation with mouth forming second NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in endoplasmic reticulum ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in extracellular space ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetyltransferase family 8 member 3
Names
N-acetyltransferase CML3
camello-like 3
camello-like protein 3
probable N-acetyltransferase CML3
NP_001032931.1
XP_017177330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037842.3 → NP_001032931.1  N-acetyltransferase family 8 member 3

    See identical proteins and their annotated locations for NP_001032931.1

    Status: VALIDATED

    Source sequence(s)
    AC162313, AK046314
    Consensus CDS
    CCDS20299.1
    UniProtKB/TrEMBL
    A0A0R4J157
    Related
    ENSMUSP00000093431.5, ENSMUST00000050780.8
    Conserved Domains (1) summary
    pfam13508
    Location:106 → 195
    Acetyltransf_7; Acetyltransferase (GNAT) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85737613..85742726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321841.2 → XP_017177330.1  N-acetyltransferase family 8 member 3 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J157
    Related
    ENSMUSP00000131413.2, ENSMUST00000168531.2
    Conserved Domains (1) summary
    pfam13508
    Location:106 → 195
    Acetyltransf_7; Acetyltransferase (GNAT) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053097.2: Suppressed sequence

    Description
    NM_053097.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIY8.1 GenPept UniProtKB/Swiss-Prot:Q9JIY8

Gene LinkOut

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