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Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 [ Mus musculus (house mouse) ]

Gene ID: 93685, updated on 2-Nov-2024

Summary

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Official Symbol
Entpd7provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 7provided by MGI
Primary source
MGI:MGI:2135885
See related
Ensembl:ENSMUSG00000025192 AllianceGenome:MGI:2135885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LALP1; Lysal2; 1810012B13Rik; 1810020C02Rik; 2810003F23Rik
Summary
Enables ribonucleoside triphosphate phosphatase activity. Involved in T-helper 17 cell differentiation and regulation of immune response. Predicted to be located in cytoplasmic vesicle membrane and nucleus. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 10.3), duodenum adult (RPKM 9.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Entpd7 in Genome Data Viewer
Location:
19 C3; 19 36.67 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43678128..43722292)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43689689..43733853)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43749453-43749636 Neighboring gene cDNA sequence BC037704 Neighboring gene STARR-positive B cell enhancer ABC_E7661 Neighboring gene cytochrome c oxidase assembly protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E11677 Neighboring gene STARR-positive B cell enhancer ABC_E5703 Neighboring gene cutC copper transporter Neighboring gene ATP-binding cassette, sub-family member 2 Neighboring gene STARR-seq mESC enhancer starr_46204

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. Kusu T, et al. J Immunol, 2013 Jan 15. PMID 23241884, Free PMC Article
  2. Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1). Shi JD, et al. J Biol Chem, 2001 May 18. PMID 11278936
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ENTPDase7 controls the luminal ATP level and, thereby, regulates Th17 cell development in the small intestine.
    Title: Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables CTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables CTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in CTP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in CTP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in CTP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GTP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UTP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UTP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleobase-containing small molecule catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing small molecule catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ribonucleoside diphosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within ribonucleoside triphosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 7
Names
NTPDase 7
lysosomal apyrase-like 2
lysosomal apyrase-like protein 1
NP_444333.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053103.5 → NP_444333.3  ectonucleoside triphosphate diphosphohydrolase 7

    See identical proteins and their annotated locations for NP_444333.3

    Status: VALIDATED

    Source sequence(s)
    AC141888, AK147401, BY773413
    Consensus CDS
    CCDS29835.1
    UniProtKB/Swiss-Prot
    B9EHD3, Q3TCT4, Q3TM04, Q571A5, Q9ET10
    Related
    ENSMUSP00000079864.6, ENSMUST00000081079.6
    Conserved Domains (1) summary
    cl17037
    Location:77 → 527
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43678128..43722292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TCT4.1 GenPept UniProtKB/Swiss-Prot:Q3TCT4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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